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- The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
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Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
write equations to illustrate the synthesis of amines by. reduction of nitriles or amides and nitro compounds. reactions involving alkyl groups: S N 2 reactions of alkyl halides, ammonia and other amines. nucleophilic attack by an azide ion on an alkyl halide, followed by reduction of the azide so formed.
Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide -based reagents used as accelerators for vulcanization. It is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators ).
- C₆H₁₃N
- 99.17
- −17.7 °C (0.1 °F; 255.5 K)
- Miscible
Oct 14, 2021 · HHS. USA.gov. 1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Jan 10, 2021 · A synthesis reaction is one of the four main types of chemical reactions, along with decomposition, single replacement, and double replacement reactions. Here is the synthesis reaction definition, examples of the reaction using elements and compounds, a look at how many reactants are involved, and how to recognize a synthesis reaction.
Mar 1, 2019 · Highlights. •. Phenol amination via cyclohexanone is possible in absence of added reductant. •. Dehydrogenation of amine allows for hydrogenation of phenol and subsequent amination. •. Nature of amine determines reactivity of the catalytic system. •. Ease and possible extent of dehydrogenation of amine are important for reactivity. Abstract.
The reaction of phenylcyclohexene with hydrogen cyanide in strongly acidic media for 2 hr. yielded a fornianiide which on acid hydrolysis produced an amine hydro- chloride whose spectral data and analysis were in agree- ment with structure IIc (Ar = phenyl).
