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  1. The reaction scheme for the synthesis of Methadone begins with the alkylation of the anion of diphenylacetonitrile (produced by reacting a strong base with diphenylacetonitrile) with 1-dimethylamino-2-chloropropane, which produces a mixture of two isomeric nitriles, one high-melting (commonly referred to as methadone nitrile), 2,2-Diphenyl-4 ...

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