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May 10, 2024 · Full size image. To examine the effect of 5′UTR RNA G-quadruplex (RG4) on translation, we inserted a potential G-quadruplex forming sequence (PQS) in between the T7 promoter and the RBS such ...
May 8, 2024 · Nature Structural & Molecular Biology - The authors elucidate by cryo-EM the mechanism by which DNA polymerases Rev1 and Polζ cooperate in translesion DNA synthesis.
2 days ago · Using directed evolution, aminoacyl-tRNA synthetases (aaRSs) have been engineered to incorporate numerous noncanonical amino acids (ncAAs). Until now, the selection of such novel aaRS mutants has relied on the expression of a selectable reporter protein. However, such translation-dependent selections are incompatible with exotic monomers that are suboptimal substrates for the ribosome. A two ...
5 days ago · The ability to read (by sequencing), write (by synthesis), and edit (by genome editing) DNA has rendered biology programmable. As an emerging discipline in synthetic biology, synthetic genomics combines the synthesis of DNA, computational design, and genomic modification of biological systems, which enables us to learn and better understand complex biological systems from the bottom-up.
Apr 30, 2024 · Translation, the synthesis of protein from RNA. Translation takes place on ribosomes, where messenger RNA molecules are read and translated into amino acid chains. These chains are then folded in various ways to form proteins. Translation follows transcription, in which DNA is decoded into RNA.
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6 days ago · Fig. 1: Biochemistry and phylogeny of the aldonolactone oxidoreductase family. Fig. 2: The crystal structure of vGalDH. In nature, L-ascorbic acid can exist in three different redox states: the ...
Apr 27, 2024 · We demonstrate that SAM-seq can be used to identify large scale chromatin compartments, discriminate active and repressed regions, obtain high-resolution profile of nucleosome positioning and DNA methylation, identify DNA footprints at occupied transcription factors binding sites, and map chromatin landscapes across lowly and highly repetitive ...
