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Oct 18, 2023 · Prazosin — Prazosin, an alpha-1 adrenergic receptor antagonist, is the best studied medication for nightmares and has been the preferred first-line pharmacotherapy when medication is deemed necessary . Trials of prazosin in patients with PTSD published subsequent to the AASM literature review have had conflicting results, however .
Aug 17, 2023 · Prazosin has therapeutic use for benign prostatic hypertrophy (BPH), post-traumatic stress disorder (PTSD) associated nightmares, Raynaud phenomenon, pheochromocytoma, and scorpion envenomation. Prazosin was the first alpha antagonist used for BPH.
Oct 8, 2010 · Prazosin demonstrated favorable clinical efficacy and was found to be safe for relieving PTSD-associated nightmares. Conclusions: Current data indicate that prazosin is an effective agent for the treatment of nightmares associated with PTSD.
Clinical Practice Guideline for Management of Post- TraumaticStressrecommendsthatcliniciansprovide prazosin to treat sleep disorders and nightmares with a level B strength of recommendation, on the basis of at least fair evidence that the intervention improves health outcomes and that benefits out- weigh harm.10.
Mar 5, 2012 · March 5, 2012. ROCHESTER, Minn. — Mayo Clinic researchers this week will announce the use of the blood pressure drug prazosin as an effective treatment to curb post-traumatic stress disorder (PTSD)-related nightmares.
Aug 9, 2012 · The prazosin dose ranged from 1 to 16 mg/d. Results were mixed for the 4 RCTs: 3 reported significant improvement in the number of nightmares, and 1 found no reduction in the number of nightmares.
Prazosin. Nightmares, frequently associated with posttraumatic stress disorder and clinically relevant in today's world of violence, are difficult to treat, with few pharmacologic options. We performed a systematic review to evaluate the evidence for the use of prazosin in the treatment of nightmares.
