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1. • • The primary outcome measure is the outcome that an investigator considers to be the most important among the many outcomes that are to be examined in the study. The primary outcome needs to be defined at the time the study is designed.
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   What is a primary outcome measure?

   • J Clin Psychiatry. 2015 Oct;76 (10):e1320-3. doi: 10.4088/JCP.15f10377. The primary outcome measure is the outcome that an investigator considers to be the most important among the many outcomes that are to be examined in the study. The primary outcome needs to be defined at the time the study is designed.

   The primary outcome measure and its importance in clinical trials

   pubmed.ncbi.nlm.nih.gov/26528658/

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   What is a primary outcome?

   • Outcomes inherently vary in importance. A primary outcome should be a measure capable of answering the main research question and is expected to directly measure at least one of the above reasons for taking risks. Treatment differences in primary outcomes generally determine whether a therapy is believed to be effective.

   Outcomes in Clinical Trials | SpringerLink

   link.springer.com/referenceworkentry/10.1007/978-3-319-52677-5_70-1

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   What is an outcome measure?

   • An outcome measure, endpoint, effect measure or measure of effect is a measure within medical practice or research, (primarily clinical trials) which is used to assess the effect, both positive and negative, of an intervention or treatment. Measures can often be quantified using effect sizes.

   Outcome measure - Wikipedia

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   What happens if the primary outcome measures are not defined?

   • Failure to pay sufficient attention to the precise definition of the primary outcome measures at the start of a trial may lead to confusion in interpreting the results or can even invalidate them. As discussed in Chapter 4 , Section 5, several different outcome measures may be employed in a trial.

   Outcome measures and case definition - Field Trials of Health

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3. pubmed.ncbi.nlm.nih.gov › 26528658The primary outcome measure and its importance in clinical ...

   pubmed.ncbi.nlm.nih.gov › 26528658

   The primary outcome measure is the outcome that an investigator considers to be the most important among the many outcomes that are to be examined in the study. The primary outcome needs to be defined at the time the study is designed. There are 2 reasons for this: it reduces the risk of false-posit …

   • Choosing a patient-important primary outcome measure ...

     This unique approach to selecting the primary outcome...

   • Outcome measures and case definition - Field Trials of Health ...

     Types of outcome measures. 2.1. Primary, secondary,...

4. en.wikipedia.org › wiki › Outcome_measureOutcome measure - Wikipedia

   en.wikipedia.org › wiki › Outcome_measure

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   An outcome measure, endpoint, effect measure or measure of effect is a measure within medical practice or research, (primarily clinical trials) which is used to assess the effect, both positive and negative, of an intervention or treatment. Measures can often be quantified using effect sizes.

5. www.nejm.org › doi › fullTrial Reporting in ClinicalTrials.gov — The Final Rule

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   Nov 17, 2016 · This requirement is designed to help ensure that results information for the primary outcome measure can be properly interpreted (see Section IV.C.4). Specification of Outcome Measures

   • Author: Deborah A. Zarin, Tony Tse, Rebecca J. Williams, Sarah Carr

   • Publish Year: 2016

6. www.nejm.org › doi › fullThe Primary Outcome Is Positive — Is That Good Enough?

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   Sep 8, 2016 · Key Questions to Ask When the Primary Outcome Is Positive. Is a P Value of Less Than 0.05 Good Enough? A P value of 0.05 carries a 5% risk of a false positive result (i.e., there is no true ...

7. link.springer.com › referenceworkentry › 10Outcomes in Clinical Trials | SpringerLink

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   Nov 19, 2020 · Primary outcomes. Secondary outcomes. Biomarker. Multiple measures. Introduction, Definitions, and General Considerations. What Is an Outcome? All studies consist of taking measurements of varying levels of complexity.