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Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations. 2...
The definition of pyrexia of unknown origin (PUO) dates back to 1961; it was described as a persistent fever above 38.3°C (100°F) that evades diagnosis for at least 3 weeks, including 1 week of investigation in hospital. 1 This definition has evolved with faster and more accurate diagnostic techniques and changing models of care, and a week ...
Sep 16, 2016 · Pyrexia of unknown origin (PUO) is a syndrome that has long tested the skills of physicians to achieve a diagnosis in affected patients. By definition, patients included in this syndrome will be more difficult to diagnose as they have already resisted classification during baseline investigations.
Key Points. |. Fever of unknown origin (FUO) is body temperature ≥ 38.3° C (≥ 101° F) rectally that does not result from transient and self-limited illness, rapidly fatal illness, or disorders with clear-cut localizing symptoms or signs or with abnormalities on common tests such as chest x-ray, urinalysis, or blood cultures.
SUMMARY POINTS. Classic adult pyrexia of unknown origin is fever of 38.3°C or greater for at least 3 weeks with no identified cause after three days of hospital evaluation or three outpatient visits Common causes are infections, neoplasms, and connective tissue disorders.
Fever of unknown origin is defined as a clinically documented temperature of 101°F or higher on several occasions, coupled with an unrevealing diagnostic workup.
n engl j med 386;5 nejm.org February 3, 2022 465 Fever of Unknown Origin generally be undertaken before a patient is con-sidered to have FUO (Fig.1), with the under -
