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Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. [1] They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production.
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a number of bacterial infections. [5] This includes bone and joint infections, intra-abdominal infections, certain types of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. [5]
- C₁₇H₁₈FN₃O₃
- Ciloxan, Cipro, Neofloxin, others
- AU: B3
Oct 1, 2019 · 1. Introduction. The quinolones are a family of antibiotics containing a bicyclic core structure related to the compound 4-quinolone (Fig. 1).1 Since their discovery in the early 1960s, they have gained increasing importance as key therapies to treat both community-acquired and severe hospital-acquired infections.2 The first quinolone antibiotic is generally considered to be nalidixic acid ...
- 10.1039/c9md00120d
- 2019/10/10
- Medchemcomm. 2019 Oct 1; 10(10): 1719-1739.
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Feb 15, 2024 · Quinolones are a type of antibiotic. Antibiotics kill or inhibit the growth of bacteria. Nalidixic acid was the first quinolone discovered, but it has since been discontinued. There are five different quinolone classes. One of the classes, called fluoroquinolones, was derived from quinolones by adding a fluorine atom to nalidixic acid.
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- What Are Quinolones and Fluoroquinolones Used for?Quinolones and fluoroquinolones are considered broad-spectrum antibiotics. This means that they are effective against a wide range of bacteria.Howe...
- What Are The Differences Between Quinolones and Fluoroquinolones?Quinolones and fluoroquinolones differ in their activity against the two enzymes produced by bacteria, topoisomerase IV and DNA gyrase. Those that...
- Are Quinolones and Fluoroquinolones Safe?Quinolones and fluoroquinolones should be avoided in children under the age of 18 years unless they have a serious infection that cannot be treated...
- What Are The Side Effects of Quinolones and Fluoroquinolones?The most commonly reported side effects include diarrhea, nausea, abnormal liver function tests, vomiting, and rash.Quinolones and fluoroquinolones...
May 22, 2023 · Quinolones are a class of broad-spectrum antibiotics used in the management and treatment of many different bacterial infections. This activity reviews the indications, contraindications, mechanism of action, adverse events, and other critical elements of quinolone therapy in the clinical setting pertinent for healthcare team members in managing the care of patients with bacterial infections ...
Dec 1, 2020 · 1. Introduction. The quinolone antibiotics (Figure 1) are the most successful class of topoisomerase inhibitors to date.They are synthetic antimicrobials with the initial compound, nalidixic acid, being discovered as a by-product of chloroquine synthesis in 1962 [1,2].
