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In Wikidata. Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. [1] They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production.
- Bacterial infection
- Drug Classes
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- Bách khoa toàn thư mở trực tuyến
- Tiếng Việt
Oct 1, 2019 · 1. Introduction. The quinolones are a family of antibiotics containing a bicyclic core structure related to the compound 4-quinolone (Fig. 1).1 Since their discovery in the early 1960s, they have gained increasing importance as key therapies to treat both community-acquired and severe hospital-acquired infections.2 The first quinolone antibiotic is generally considered to be nalidixic acid ...
- 10.1039/c9md00120d
- 2019/10/10
- Medchemcomm. 2019 Oct 1; 10(10): 1719-1739.
Tìm hiểu về kháng sinh nhóm quinolon. Kháng sinh nhóm quinolon là một trong những kháng sinh vô cùng quan trọng với phổ tác dụng rộng, được ứng dụng phổ biến trong điều trị các bệnh lý nhiễm khuẩn. Khi được chỉ định dùng kháng sinh quinolon, người bệnh cần tuân thủ theo ...
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Jul 15, 2005 · Modifications to the quinolone nucleus. A new key finding in the evolution of quinolones was modification of the quinolone nucleus through the addition of different substituents at the N-1, C-6, C-7, and C-8 positions [4, 13] (see also figure 1 in Owens and Ambrose ). These modifications altered the antimicrobial activity, pharmacokinetics, and ...
- Vincent T. Andriole
- 2005
Dec 1, 2020 · Figure 6. Model of quinolone lethality. (1) Quinolones stabilise the topoisomerase-DNA cleavage complex in which there is a double-strand break. (2) If the cleavage complex is not resolved, (3) replication and transcription cannot happen, which causes slow bacterial cell death.
May 22, 2023 · Quinolones are a class of broad-spectrum antibiotics used in the management and treatment of many different bacterial infections. This activity reviews the indications, contraindications, mechanism of action, adverse events, and other critical elements of quinolone therapy in the clinical setting pertinent for healthcare team members in managing the care of patients with bacterial infections ...
