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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
May 25, 2022 · The raphe nuclei comprise nearly all of 5-hydroxytryptaminergic (5-HTergic) neurons in the brain and are widely acknowledged to participate in the modulation of neural excitability.
Jul 24, 2023 · The raphe nuclei are located midline throughout the brainstem within the pons, midbrain, and medulla. The majority of neurons located in the raphe nuclei are serotonergic. The more rostral raphe nuclei appear to be important in various bodily functions, including pain sensation and mood regulation.
Jul 24, 2023 · The raphe nuclei form a central ridge of the reticular formation and play an important role in mood regulation and arousal through neurotransmission via serotonin and projections to the limbic regions. The medial column of the gigantocellular reticular nuclei is composed of larger neurons and coordinates motor movements.
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
Situated along the medial tegmental field ventral to the aqueduct (rostral) and the fourth ventricle (caudal), the raphe nuclei are divided rostrocaudally to dorsal raphe nucleus (DRN), linear nucleus, median raphe nucleus, pontine nucleus, magnus raphe nucleus, pallidal raphe nucleus, and obscurus raphe nucleus (Olszewski & Baxter, 1982).
