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    The raphe nuclei provide feedback to the suprachiasmatic nuclei (SCN), thus contributing in circadian rhythms in animals. The SCN transmits to the raphe nuclei via the dorsomedial hypothalamic nucleus altering serotonin levels for sleep/wake states. The raphe nuclei will then transmit feedback to the SCN about the animal's vigilance and levels ...

  2. Connections of the raphe nuclei with the forebrain develop at 7–8 weeks (stages 21–23), probably via the central tegmental tract, and the nuclei come to be situated within the septum medullae (stage 23). Two distinct raphe nuclei at 8 weeks (stage 23) have been reconstructed (O'Rahilly and Müller, 1999a, figures 23-27).

  3. Raphe nuclei contain many different types of cells that have many different functions. Raphe cells can be distinguished on the basis of their phenotype, as a combination of (neurotransmitter content), projections (e.g., spinal cord vs. cortex) and functions (a difficult mechanistic problem based on the suite of neurotransmitters released at any ...

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  5. May 08, 2021 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections. Serotonin generation comes from L-tryptophan via a two-step process catalyzed by tryptophan hydroxylase and L-aromatic amino ...

    • Emily P. Walker, Prasanna Tadi
    • 2019
  6. The raphe pallidus nucleus is the smallest of the raphe nuclei. The projections from the raphe nuclei are pervasive, carrying serotonin throughout the central nervous system. Thus, the functions that can be linked back to the raphe nuclei are also extensive and complex. There are, however, several functions that have a recognized association ...

  7. Mar 02, 2021 · The raphe nuclei, which are neuronal aggregates divided into paired nuclei along the brainstem, perform vital functions related to stimulus responsiveness, sleep, and wakefulness. However, the most important and best known of all is the release of the neurotransmitter serotonin. The brain is the most-studied organ.

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