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How many serotonin neurons are in the human raphe nuclei?
What physiology is a serotonergic pathway originating from the raphe nuclei?
Are raphe nuclei cytoarchitectonic?
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
Serotonin. The raphe nuclei are distributed near the midline of the brainstem along its entire rostro-caudal extension. The serotonergic neurons are their main neuronal components, although a proportion of them lie in subdivisions of the lateral reticular formation. They develop from mesopontine and medullary ….
- Jean-Pierre Hornung
- 2003
In the central nervous system (CNS), serotonin is almost exclusively produced in neurons originating in the raphe nuclei located in the midline of the brainstem. These serotonin-producing neurons form the largest and most complex efferent system in the human brain.
- Miles Berger, John A. Gray, Bryan L. Roth
- 10.1146/annurev.med.60.042307.110802
- 2009
- 2009
Dec 1, 2003 · With a total number of about half a million in the human raphe nuclei, serotonin neurons have a dense and divergent projection extending to all divisions of the brain, but still with a specific areal and cellular targeting in different circuits of the sensory, motor or limbic systems.
- Jean-Pierre Hornung
- 2003
May 1, 2023 · Serotonin primarily metabolized by monoamine oxidase. The more rostral nuclei located in the midbrain and rostral pons – caudal linear nucleus, dorsal raphe, and median raphe – have projections which extend to forebrain structures.
- Emily P. Walker, Prasanna Tadi
- 2019
The importance of raphe nuclei in circadian rhythms, especially in photic responses, has been demonstrated in many studies. Serotonin is the raphe neurotransmitter that triggers phase shifts, inhibits light-induced phase-shifts, and plays a role in controlling the sleep-wake cycle.
Sep 25, 2018 · Serotonin neurotransmission is tightly regulated by autoreceptors (serotonin receptors expressed by serotonin neurons) known to act through negative feedback inhibition at the cell bodies...