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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
The nucleus raphe pallidus has also been known to mediate the tachycardia response, an extremely high heart rate known to be incited by emotional or psychological stress. Microinjections of a GABA-a antagonist into the nucleus raphe pallidus, induces an increased heart rate. Conversely, microinjections of muscimol, a GABA-a agonist, inhibit ...
- nucleus raphe pallidus
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May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
It has enkephalin -producing cells that suppress pain. The periaqueductal gray is the gray matter located around the cerebral aqueduct within the tegmentum of the midbrain. It projects to the nucleus raphe magnus, and also contains descending autonomic tracts.
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May 25, 2022 · Numerous researches have shown that the raphe nuclei 5-hydroxytryptamine (5-HT)ergic system plays an important role not only in many physiological functions such as mood regulation, but also in ...
Aug 14, 2019 · The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders. The DRN is subdivided into distinct anatomical subregions comprised of multiple cell types, and its complex cellular organization has impeded efforts to investigate the distinct circuit and ...
The Raphe nuclei (singular = Raphe nucleus) are a cluster of nuclei in the hindbrain which release a neurotransmitter called serotonin (5-HT). The serotonin molecules get sent all over the brain, where they are needed for all sorts of roles. [1] '. Selective serotonin reuptake inhibitor' (SSRI) antidepressants are believed to act in these ...
