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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
The reticular formation is divided into three columns: raphe nuclei (median), gigantocellular reticular nuclei (medial zone), and parvocellular reticular nuclei (lateral zone). The raphe nuclei are the place of synthesis of the neurotransmitter serotonin, which plays an important role in mood regulation.
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May 1, 2023 · See more... The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
May 25, 2022 · Numerous researches have shown that the raphe nuclei 5-hydroxytryptamine (5-HT)ergic system plays an important role not only in many physiological functions such as mood regulation, but also in ...
The dorsal raphe nucleus is one of the raphe nuclei. It is situated in the brainstem at the midline. It has rostral and caudal subdivisions: The rostral aspect of the dorsal raphe is further divided into interfascicular, ventral, ventrolateral and dorsal subnuclei.
- nucleus raphes posterior, nucleus raphes dorsalis
- birnlex_982
Aug 14, 2019 · The dorsal raphe nucleus (DRN) is a major source of neuromodulators in the central nervous system, and is the largest of the serotonergic nuclei, containing approximately a third of all serotonergic neurons (5-HT neurons) in the brain ( Hornung, 2010 ). DRN 5-HT neurons send highly divergent projections that target many functionally distinct ...
Jan 11, 2016 · The serotonergic raphe nuclei are involved in regulating brain states over timescales of minutes and hours. We examined more rapid effects of raphe activation on two classes of principal neurons ...
