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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
The reticular formation is divided into three columns: raphe nuclei (median), gigantocellular reticular nuclei (medial zone), and parvocellular reticular nuclei (lateral zone). The raphe nuclei are the place of synthesis of the neurotransmitter serotonin, which plays an important role in mood regulation.
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
Aug 14, 2019 · The dorsal raphe nucleus (DRN) is a major source of neuromodulators in the central nervous system, and is the largest of the serotonergic nuclei, containing approximately a third of all serotonergic neurons (5-HT neurons) in the brain (Hornung, 2010).
- Kee Wui Huang, Nicole E Ochandarena, Adrienne C Philson, Minsuk Hyun, Jaclyn E Birnbaum, Marcelo Cic...
- 2019
Jul 27, 2017 · The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN. Main Text. Hunger is a complex motivational state that engages a distributed neural system to promote food-seeking behaviors.
- Hui Yang, Scott M. Sternson
- 2017
N. Dafny, G.C. Rosenfeld, in Conn's Translational Neuroscience, 2017. Raphe Nuclei. The RN is a collective term of several nerve cell groups in and along the median plane of the medulla oblongata. These nuclei include neurons that synthesize 5HT.
May 25, 2022 · Qiu-wen Lou, Zhong Chen & Yi Wang. Acta Pharmacologica Sinica 43 , 2777–2788 ( 2022) Cite this article. 768 Accesses. 3 Citations. Metrics. Abstract. The raphe nuclei comprise nearly all of...
