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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections. Serotonin generation comes from L-tryptophan via a two-step process catalyzed by tryptophan hydroxylase and L-aromatic amino ...
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
Aug 14, 2019 · The dorsal raphe nucleus (DRN) is a major source of neuromodulators in the central nervous system, and is the largest of the serotonergic nuclei, containing approximately a third of all serotonergic neurons (5-HT neurons) in the brain ( Hornung, 2010 ). DRN 5-HT neurons send highly divergent projections that target many functionally distinct ...
- Kee Wui Huang, Nicole E Ochandarena, Adrienne C Philson, Minsuk Hyun, Jaclyn E Birnbaum, Marcelo Cic...
- 2019
May 25, 2022 · Numerous researches have shown that the raphe nuclei 5-hydroxytryptamine (5-HT)ergic system plays an important role not only in many physiological functions such as mood regulation, but also in ...
The Median Raphe Nucleus is a part of the Raphe Nucleus. The median raphe nucleus ( MRN or MnR ), also known as the nucleus raphes medianus ( NRM) [1] or superior central nucleus, is a brain region composed of polygonal, fusiform, and piriform neurons, which exists rostral to the nucleus raphes pontis. The MRN is located between the posterior ...
- nucleus raphes medianus, nucleus centralis superior
- 562
Aug 14, 2019 · Abstract. The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders. The DRN is subdivided into distinct anatomical subregions comprised of multiple cell types, and its complex cellular organization has impeded efforts to investigate the distinct ...
The nucleus raphe magnus (termed the nucleus raphes magnus by Terminologia Anatomica [1] and some publications [2]) is one of the seven raphe nuclei. It is situated in the pons in the brainstem, [3] : 306 just rostral to the nucleus raphe obscurus. [citation needed] The NRM receives afferent stimuli from the enkephalinergic neurons of the ...
