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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections. Serotonin generation comes from L-tryptophan via a two-step process catalyzed by tryptophan hydroxylase and L-aromatic amino ...
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
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The reticular formation is a set of interconnected nuclei that are located in the brainstem, hypothalamus, and other regions. It is not anatomically well defined, because it includes neurons located in different parts of the brain. The neurons of the reticular formation make up a complex set of networks in the core of the brainstem that extend ...
The dorsal raphe nucleus is one of the raphe nuclei. It is situated in the brainstem at the midline. It has rostral and caudal subdivisions: The rostral aspect of the dorsal raphe is further divided into interfascicular, ventral, ventrolateral and dorsal subnuclei. The projections of the dorsal raphe have been found to vary topographically, and ...
- nucleus raphes posterior, nucleus raphes dorsalis
- birnlex_982
Aug 14, 2019 · The dorsal raphe nucleus (DRN) is a major source of neuromodulators in the central nervous system, and is the largest of the serotonergic nuclei, containing approximately a third of all serotonergic neurons (5-HT neurons) in the brain ( Hornung, 2010 ). DRN 5-HT neurons send highly divergent projections that target many functionally distinct ...
- Kee Wui Huang, Nicole E Ochandarena, Adrienne C Philson, Minsuk Hyun, Jaclyn E Birnbaum, Marcelo Cic...
- 2019
Aug 27, 2013 · Activity level of the raphe nuclei is also modulated; it is increased under inescapable shocks (Grahn et al., 1999; Takase et al., 2004). Forced swimming induced an increase or decrease in 5-HT levels, as measured by microdialysis, depending on the brain region examined; its levels increased in the striatum, but decreased in the amygdala and ...
May 25, 2022 · Numerous researches have shown that the raphe nuclei 5-hydroxytryptamine (5-HT)ergic system plays an important role not only in many physiological functions such as mood regulation, but also in ...
