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The raphe nuclei ( Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
May 1, 2023 · Last Update: May 1, 2023. Go to: Introduction. The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
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May 25, 2022 · Numerous researches have shown that the raphe nuclei 5-hydroxytryptamine (5-HT)ergic system plays an important role not only in many physiological functions such as mood regulation, but also in ...
The raphe nucleus is considered to be part of the reticular formation and is located in the brainstem. It is responsible for the release of serotonin to other parts of the brain. Selective serotonin reuptake inhibitor (SSRI) drugs, for example, are thought to act on the raphe nucleus.
Aug 1, 2015 · For the same reason, the number of functional voxels was 18±3 for DR and 11±2 for MR. The median correlation between the DR and MR raw time-series was 0.26 (range −0.24 − 0.62). Figure 1. (A) Structural MRI image. The raphe nuclei are not identifiable.
- Vincent Beliveau, Claus Svarer, Vibe G. Frokjaer, Gitte Moos Knudsen, Douglas N. Greve, Patrick M. F...
- 10.1016/j.neuroimage.2015.04.065
- 2015
- 2015/08/08
Definition. The raphe nuclei are a moderate-size cluster of nuclei found in the brain stem. Their main function is to release serotonin to the rest of the brain. The raphe nuclei are traditionally considered to be the medial portion of the reticular formation, and appear as a ridge of cells in the center and most medial portion of the brain ...
These nuclei, located on the midline (raphe or seam) of the brain stem, are all serotonergic. In the caudal midbrain, for example, the “raphe” contains the “dorsal raphe nucleus” and the “superior central nucleus,” collectively referred to as the “midbrain raphe.”. These two cell groups have diffuse ascending serotonergic ...
