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Culture-proven neonatal sepsis or meningitis was found in 15 of 833 (1.8%) neonates, and 101 of the remaining 818 (12.3%) infants were suspected to have sepsis or pneumonia. Multivariate analysis of risk factors for proven neonatal sepsis demonstrated a statistically significant association with decreasing gestational age, duration of internal ...
- Michael K. Yancey, Patrick Duff, Patrick Duff, Paul Kubilis, Paul Kubilis, Penny Clark, Penny Clark,...
Background: Factors associated with neonatal sepsis, an important cause of child mortality, are poorly described in Africa. We characterized factors associated with early-onset (days 0-2 of life) and late-onset (days 3-28) -sepsis and perinatal death among infants enrolled in the Prevention of Perinatal Sepsis Trial (NCT00136370 at ClinicalTrials.gov), Soweto, South Africa.
- Stephanie J. Schrag, Clare L. Cutland, Elizabeth R. Zell, Locadiah Kuwanda, Eckhart J. Buchmann, Sit...
May 10, 2016 · Objectives Neonatal sepsis is a leading cause of neonatal morbidity and mortality, particularly in the developing countries. Delays in the identification and treatment of neonatal sepsis are among the main contributors to the high mortality. The aim of this study was to determine the risk factors of neonatal sepsis in public hospitals of Mekelle City, Tigray Region, North Ethiopia, 2015 ...
- Destaalem Gebremedhin, Haftu Berhe, Kahsu Gebrekirstos
- Materials and Methods
- Data Availability
Worldwide, neonatal sepsis accounts for an estimated 26% of under-five deaths, with sub-Saharan Africa having the highest mortality rates. Though worldwide neonatal deaths have decreased by over 3.6 million per year since 2000, neonatal sepsis remains a notable hindrance to the progress in the decline of cause-specific mortality rates especially in sub-Saharan Africa. This study aimed at examining the risk factors of neonatal sepsis at the Trauma and Specialist Hospital, Winneba. The study was an unmatched case control retrospective study. Cases were neonates who had sepsis with their index mothers and controls were neonates who did not have sepsis with their index mothers. Neonatal and maternal medical records were retrieved from January to December 2017. Data abstraction lasted for one month and 2650 folders for the neonates and their index mothers were retrieved. Nine hundred (900) neonatal folders were considered valid for the study and likewise for the maternal folders. One hun...
Worldwide, neonatal sepsis accounts for an estimated 26% of under-five deaths, with sub-Saharan Africa (SSA) having the highest mortality rates. Sub-Saharan Africa has an uneven burden of neonatal mortality, leading to an estimated 49.6% of all under-five deaths in 2013 [1 1. L. Liu, S. Oza, D. Hogan et al., “Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis,” Lancet, vol. 385, pp. 430–440, 2015. View at: Google Scholar See in References ]. The third Sustainable Development Goal for child health aims to end preventable deaths of newborns and children under five years of age by 2030; this goal may not be attained without significant reduction of neonatal mortalities directly related to infection in developing countries [2 1. S. L. Ranjeva, B. C. Warf, and S. J. Schiff, “Economic burden of neonatal sepsis in sub-Saharan Africa,” BMJ Global Health, vol. 3, no. 1, p. e000347, 2018. View at...
This was an unmatched retrospective case control study conducted among 900 neonates born within January to December 2017 at the Trauma and Specialist Hospital, Winneba, Ghana. Neonatal sepsis (cases) were diagnosed based on hematological criteria (total leukocyte count, neutrophil count, erythrocyte sedimentation rate (ESR), and platelet count) and Integrated Management of Neonatal and Childhood Illness (IMNCI) clinical features (of either fever (≥37.5°C) or hypothermia (≤35.5°C), fast breathing (≥60 breathes per minute), not feeding well, severe chest in-drawing, movement only when stimulated, convulsion, lethargy, or unconsciousness). Some diagnoses were made based on the clinical features due to parents not being able to afford laboratory services. The setting of the study was the Trauma and Specialist Hospital, Winneba. The Trauma and Specialist Hospital serves as the regional hospital for the Central Region of Ghana. The pediatric ward doubles as the Neonatal Intensive Care Uni...
In the current study, a total of 103 neonates who had sepsis (cases) with their index mothers and 797 neonates who had no sepsis (controls) with their index mothers were enrolled. The majority of mothers were within the age range of 20-29 years, constituting 62 (60.2%) of cases and 460 (57.7%) of controls. Ninety-one (88.3%) cases and 653 (81.9%) controls were married. Christianity was the dominant religion among the mothers of cases and controls, 85.4% and 85.6%, respectively. Fifteen (14.6%) of cases and 96 (12.0%) of controls were not educated. It was also realized that 24 (23.3%) of cases and 106 (13.3%) of controls were housewives by occupation. In relation to the neonates’ sociodemographic characteristics, 25 (24.3%) of the cases and 255 (32.0%) controls were found within the age of 4-7 days (Table 1). Thirty-five (34.0%) of cases and 472 (59.2%) of controls had spontaneous vaginal delivery. It was noted that the majority of the cases 67 (65.0%) were delivered through cesarean...
The present study assessed maternal and neonatal risk factors of neonatal sepsis in order to tackle the disease burden and its specific associated problems. The current study finding revealed that the probability that a neonate develops sepsis increased with increasing neonatal age. It was also realized that three-fourths of the cases (78.7%) had early onset of neonatal sepsis (<7days). The present study finding is congruent with the study conducted by Gebremedhin, Berhe, and Gebrekirstos [12 1. D. Gebremedhin, H. Berhe, and K. Gebrekirstos, “Risk factors for neonatal sepsis in public hospitals of Mekelle City, North Ethiopia, 2015: Unmatched case control study,” PLoS ONE, vol. 11, no. 5, Article ID e0154798, 2016. View at: Publisher Site| Google Scholar See in References ] in Ethiopia where they found three-fourths (76.9%) of cases having early onset of neonatal sepsis. Also there was a slightly higher comparable percentage on early onset of neonatal sepsis in other studies conduct...
The study found both maternal and neonatal factors as possible independent risk factors to have a strong association with the risk of neonatal sepsis. The study also observed that the majority of the neonates had early onset of sepsis. Therefore, encouraging mothers to utilize antenatal services might help identify the risk factors and possible interventions to minimize the risk factors of adverse birth outcomes including neonatal sepsis. And also healthcare personnel improving the care they render to mothers and babies could be a key factor in reducing neonatal sepsis.
The data used to support the findings of this study are available from the corresponding author upon request.
The authors wish to thank the management of the Trauma and Specialist Hospital, Winneba, for their support in making this study a success.
- Peter Adatara, Agani Afaya, Solomon Mohammed Salia, Richard Adongo Afaya, Kennedy Diema Konlan, Eric...
Risk factors associated to the development of neonatal sepsis were prematurity (OR 9.33; p < 0.001), low birth weight (OR 11.74; p < 0.001), maternal infection (OR 2.28; p = 0.009), mother with ...