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  1. Roseola - Wikipedia

    Roseola, also known as sixth disease, is an infectious disease caused by certain types of virus. Most infections occur before the age of three. Symptoms vary from absent to the classic presentation of a fever of rapid onset followed by a rash.

    • Signs and Symptoms
    • Cause
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    • History

    Rose­ola typ­i­cally af­fects chil­dren be­tween six months and two years of age, and be­gins with a sud­den high fever (39–40 °C; 102.2-104 °F). In rare cases, this can cause febrile con­vul­sions (also known as febrile seizures or "fever fits") due to the sud­den rise in body tem­per­a­ture, but in many cases the child ap­pears nor­mal. After a few days the fever sub­sides, and just as the child ap­pears to be re­cov­er­ing, a red rash ap­pears. This usu­ally be­gins on the trunk and then spreads to the arms, legs, and neck. The rash is not itchy and may last 1 to 2 days. In con­trast, a child suf­fer­ing from measles would usu­ally ap­pear sicker, with symp­toms of con­junc­tivi­tis, cold-like symp­toms, and a cough, and their rash would af­fect the face and last for sev­eral days. Liver dys­func­tion can occur in rare cases. A small per­cent­age of chil­dren ac­quire HHV-6 with few sign or symp­toms of the dis­ease. Ex­an­thema subi­tum oc­curs in ap­prox­i­mately 30% of chil­dr...

    Rose­ola is caused by two human her­pesviruses, human her­pesvirus 6 (HHV-6) and human her­pesvirus 7 (HHV-7), which are some­times re­ferred to col­lec­tively as Rose­olovirus. There are two vari­ants of HHV-6 (HHV-6a and HHV-6b) and stud­ies in the US, Eu­rope, Dubai and Japan have shown that ex­an­thema subi­tum is caused by HHV-6b. This form of HHV-6 in­fects over 90% of in­fants by age 2.

    There is no spe­cific vac­cineagainst or treat­ment for ex­an­thema subi­tum, and most chil­dren with the dis­ease are not se­ri­ously ill.

    Most cases of HHV-6 in­fec­tion get bet­ter on their own. If en­cephali­tis oc­curs gan­ci­clovir or fos­car­netmay be useful.

    John Za­horsky MD wrote ex­ten­sively on this dis­ease in the early 20th cen­tury, his first for­mal pre­sen­ta­tion was to the St Louis Pe­di­atric so­ci­ety in 1909 where he de­scribed 15 young chil­dren with the ill­ness. In a JAMA ar­ti­cle pub­lished on Oct 18, 1913 he noted that "the name 'Rose­ola in­fan­tilis' had an im­por­tant place in the med­ical ter­mi­nol­ogy of writ­ers on skin dis­eases" but that de­scrip­tions of the dis­ease by pre­vi­ous writ­ers tended to con­fuse it with many other dis­eases that pro­duce febrile rashes. In this JAMA ar­ti­cle Za­horsky re­ports on 29 more chil­dren with Rose­ola and notes that the only con­di­tion that should se­ri­ously be con­sid­ered in the dif­fer­en­tial di­ag­no­sis is Ger­man Measles (rubella) but notes that the fever of rubella only lasts a few hours whereas the pro­dro­mal fever of Rose­ola lasts thee to five days and dis­ap­pears with the for­ma­tion of a mor­bil­li­formrash.

  2. Roseolovirus - Wikipedia

    The acquisition of HHV-6 in infancy is often symptomatic, resulting in childhood fever, diarrhea, and exanthem subitum rash (commonly known as roseola). Although rare, this initial infection can also cause febrile seizures , encephalitis or intractable seizures.

  3. Fifth disease - Wikipedia

    Fifth disease starts with a low-grade fever, headache, rash, and cold-like symptoms, such as a runny or stuffy nose. These symptoms pass, then a few days later, the rash appears. The bright red rash most commonly appears in the face, particularly the cheeks. This is a defining symptom of the infection in children (hence the name "slapped cheek ...

    • virus
    • Red rash, especially on cheeks
    • Slapped cheek syndrome, slapcheek, slap face, slapped face
    • Infectious disease
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  5. Roseola infantum - WikEM

    Roseola on a 21-month-old girl 3-5d prodrome of high fever → then defervescence → then rash for 1-2d Rash - erythematous macular eruption of discrete, pink lesions

  6. Roseola infantum | disease | Britannica

    Roseola infantum, infectious disease of early childhood marked by rapidly developing high fever (to 106° F) lasting about three days and then subsiding completely. A few hours after the temperature returns to normal, a mildly itchy rash develops suddenly on the trunk, neck, and behind the ears but

  7. A child may not have any symptoms for 5-15 days after getting the virus that causes roseola. When symptoms do appear, the first thing you’ll notice is a sudden, high fever (over 103 F) that ...

  8. Roseola - Symptoms and causes - Mayo Clinic
    • Overview
    • Symptoms
    • Causes
    • Risk Factors
    • Complications
    • Prevention

    Roseola is a generally mild infection that usually affects children by age 2. It occasionally affects adults. Roseola is so common that most children have been infected with roseola by the time they enter kindergarten.Two common strains of the herpes virus cause roseola. The condition typically causes several days of fever, followed by a rash.Some children develop only a very mild case of roseola and never show any clear indication of illness, while others experience the full range of signs a...

    If your child is exposed to someone with roseola and becomes infected with the virus, it generally takes a week or two for signs and symptoms of infection to appear — if they appear at all. It's possible to become infected with roseola, but have signs and symptoms too mild to be readily noticeable. Roseola symptoms may include: 1. Fever. Roseola typically starts with a sudden, high fever — often greater than 103 F (39.4 C). Some children also may have a sore throat, runny nose or cough along...

    The most common cause of roseola is the human herpes virus 6, but the cause also can be another herpes virus — human herpes virus 7.Like other viral illnesses, such as a common cold, roseola spreads from person to person through contact with an infected person's respiratory secretions or saliva. For example, a healthy child who shares a cup with a child who has roseola could contract the virus.Roseola is contagious even if no rash is present. That means the condition can spread while an infec...

    Older infants are at greatest risk of acquiring roseola because they haven't had time yet to develop their own antibodies against many viruses. While in the uterus, babies receive antibodies from their mothers that protect them as newborns from contracting infections, such as roseola. But this immunity decreases with time. The most common age for a child to contract roseola is between 6 and 15 months.

    Occasionally a child with roseola experiences a seizure brought on by a rapid rise in body temperature. If this happens, your child might briefly lose consciousness and jerk his or her arms, legs or head for several seconds to minutes. He or she may also lose bladder or bowel control temporarily.If your child has a seizure, seek emergency care. Although frightening, fever-related seizures in otherwise healthy young children are generally short-lived and are rarely harmful.Complications from r...

    Because there's no vaccine to prevent roseola, the best you can do to prevent the spread of roseola is to avoid exposing your child to an infected child. If your child is sick with roseola, keep him or her home and away from other children until the fever has broken.Most people have antibodies to roseola by the time they're of school age, making them immune to a second infection. Even so, if one household member contracts the virus, make sure that all family members wash their hands frequentl...

  9. Roseola: Symptoms, Treatment, and More

    Aug 30, 2018 · The most common symptoms of roseola are a sudden, high fever followed by a skin rash. A fever is considered high if your child’s temperature is between 102 and 105°F (38.8-40.5°C).

  10. Measles - Wikipedia

    Once the measles virus gets onto the mucosa, it infects the epithelial cells in the trachea or bronchi. Measles virus uses a protein on its surface called hemagglutinin (H protein), to bind to a target receptor on the host cell, which could be CD46, which is expressed on all nucleated human cells, CD150, aka signaling lymphocyte activation molecule or SLAM, which is found on immune cells like ...