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3 days ago · Chapter 1 deals with the approach that this book takes to the study of pharmaceutics. It makes the point that the drug and its dosage form must be considered together. The dosage form may significantly alter the impact of the drug and, in certain instances, actually change the nature of the observed pharmacological response.
5 days ago · Oral administration (PO: per os – by mouth) is a route where a substance (e.g. tablet, syrup) is taken through the mouth to be absorbed from the stomach or intestine, enters the liver and the general circulation. This method is used in 80% of the medicines used in medical practice because the route is convenient and economical.
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5 days ago · Each route has several variations, and each offers distinct advantages and disadvantages. The key features of various routes are discussed here (see Table 2-1). For a more detailed description of the specific methodology involved in drug administration, the references at the end of this chapter include several excellent resources on this topic ...
4 days ago · View Full Size | | Download Slide (.ppt) Scheme demonstrating the dynamic relationship between the drug, the drug product, and the pharmacologic effect. First, the drug in its dosage form is taken by the patient either by an oral, intravenous, subcutaneous, transdermal, etc, route of administration.
3 days ago · Bioavailability is calculated by comparing plasma levels of a drug given via a particular route of administration (for example, orally) with plasma drug levels achieved by IV injection. This is where the AUC comes into play (the area under the curve calculated by plotting plasma concentrations of the drug versus time).
