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  1. Feb 10, 2021 · Background. Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an...

  2. May 1, 2024 · Updated on May 1, 2024. Key takeaways: In 2021, semaglutide (marketed as Wegovy) became the first once-weekly medication in its class to be FDA approved for chronic weight management. It works best when used in combination with a healthy diet and routine exercise.

  3. Jan 12, 2023 · After 68 weeks, half of the participants using semaglutide lost 15% of their body weight, and nearly a third lost 20%. Participants who incorporated only lifestyle changes lost about 2.4% of their weight. Since then, additional studies have shown similar results.

  4. Apr 3, 2024 · Wegovy is approved for weight loss use alongside a reduced-calorie diet and increased exercise in adults with a body mass index (BMI) greater than 27–30, or children 12 and older with a higher-than-average BMI for their age and sex. Wegovy is also approved to reduce the risk of serious heart problems in adults with obesity or who are overweight.

  5. Aug 3, 2023 · In fact, a 2021 phase 3 clinical trial found that 2.4 milligram weekly semaglutide injections produced a mean weight loss of 14.9% (versus 2.4% with a placebo) after 68 weeks in people with a...

  6. Among those taking semaglutide, weight loss continued to week 65 and was sustained over the trial, with the participants’ losing on average 10.2 per cent of their body weight, compared with 1.5 ...

  7. Oct 10, 2022 · Article. Open access. Published: 10 October 2022. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial. W. Timothy Garvey, Rachel L. Batterham, Meena Bhatta,...

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