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  2. Sepsis-related death rates for adults aged 75–84 followed the same pattern as all adults aged 65 and over and declined from 343.0 in 2000 to 331.8 in 2019. While variable over time, sepsis-related death rates for adults aged 85 and over generally declined between 2000 (820.3) and 2019 (750.0).

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    Symptoms of sepsis

    Symptoms of sepsis may include:

    Symptoms of septic shock

    Sepsis may progress to septic shock. Septic shock is a severe drop in blood pressure. Progression to septic shock raises the risk of death. Symptoms of septic shock include:

    Any infection could lead to sepsis. Go to a health care provider if you have symptoms of sepsis or an infection or wound that isn't getting better.

    Symptoms such as confusion or fast breathing need emergency care.

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    Any type of infection can lead to sepsis. This includes bacterial, viral or fungal infections. Those that more commonly cause sepsis include infections of:

    •Lungs, such as pneumonia.

    •Kidney, bladder and other parts of the urinary system.

    •Digestive system.

    •Bloodstream.

    •Catheter sites.

    Some factors that increase the risk infection will lead to sepsis include:

    •People over age 65.

    •Infancy.

    •People with lower immune response, such as those being treated for cancer or people with human immunodeficiency virus (HIV).

    •People with chronic diseases, such as diabetes, kidney disease or chronic obstructive pulmonary disease (COPD).

    •Admission to intensive care unit or longer hospital stays.

    As sepsis worsens, vital organs, such as the brain, heart and kidneys, don't get as much blood as they should. Sepsis may cause atypical blood clotting. The resulting small clots or burst blood vessels may damage or destroy tissues.

    Most people recover from mild sepsis, but the mortality rate for septic shock is about 30% to 40%. Also, an episode of severe sepsis raises the risk for future infections.

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    By Mayo Clinic Staff

    Feb 10, 2023

    1.Forrester JD. Sepsis and septic shock. Merck Manual Professional Version. https://www.merckmanuals.com/professional/critical-care-medicine/sepsis-and-septic-shock/sepsis-and-septic-shock. Accessed Nov. 19, 2022.

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  3. Oct 10, 2023 · While sepsis-related deaths declined from 2000 to 2019 (thanks in part to the first Surviving Sepsis Campaign guidelines, which were published in 2004 and most recently updated in 2021), the mortality rates have recently increased from 277 per 100,000 people age 65 and over in 2019 to 331 per 100,000 in the same age group in 2021, according to t...

  4. Feb 15, 2023 · Septicemia Mortality by State. Print. Sepsis is the body’s extreme response to an infection. If not identified and treated quickly, sepsis may lead to serious medical consequences and death. For more information on sepsis. 1 The number of deaths per 100,000 total population. Source: https://wonder.cdc.gov.

  5. May 3, 2024 · From data published in 2020, there were 48.9 million cases and 11 million sepsis-related deaths worldwide, representing 20% of all global deaths (2). Almost half (20 million) of all estimated sepsis cases worldwide occurred in children under 5 years of age.

  6. Sep 21, 2023 · In 2021, the sepsis-related death rate among persons aged ≥65 years was 330.9 deaths per 100,000 population; the rate among men (371.7) was higher than that among women (297.4).

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