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  1. May 14, 2021 · Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology.

  2. Feb 10, 2023 · Overview. Sepsis is a serious condition in which the body responds improperly to an infection. The infection-fighting processes turn on the body, causing the organs to work poorly. Sepsis may progress to septic shock. This is a dramatic drop in blood pressure that can damage the lungs, kidneys, liver and other organs.

  3. Mar 21, 2019 · Sepsis is a systemic response to infection, manifested by two or more of the SIRS criteria as a result of infection. Severe sepsis: Sepsis associated with organ dysfunction, hypoperfusion, or hypotension; hypoperfusion and perfusion abnormalities may include, but not limited to, lactic acidosis, oliguria, or an acute alteration in mental status

  4. Jan 18, 2024 · Sepsis results when the response to infection becomes generalized and involves normal tissues remote from the site of injury or infection. The pathophysiology of sepsis and mechanisms of multiple organ system dysfunction are reviewed here. The definition and management of sepsis are discussed separately.

  5. May 23, 2016 · In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune dysfunction and catabolism. Much has been learnt about the pathogenesis of sepsis at the molecular, cell, and intact organ level.

  6. May 3, 2024 · Overview. Sepsis is a life-threatening condition that happens when the body’s immune system has an extreme response to an infection, causing organ dysfunction (4).The body’s reaction causes damage to its own tissues and organs and it can lead to shock, multiple organ failure and sometimes death, especially if not recognized early and treated promptly.

  7. May 21, 2023 · Review the pathophysiology of bacterial sepsis. Describe the typical lab findings in bacterial sepsis. Summarize the components of the acute sepsis bundle and the components of the sepsis management bundle used in the evaluation and treatment of patients with sepsis.

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