Von Willebrand disease is a distinct disorder, it is not hemophilia. Classification There are three variants or forms of vWD (types 1,2,3) defined by the quantity and structure of plasma von Willebrand factor (abbreviated vWF) in affected dogs. Within each breed a single form of vWD predominates.
- 0 to 49
- 70 to 180
- 50 to 69
The results of coagulation panel testing will be normal in dogs with von Willebrand's disease. Specific Tests: Dogs with a history of unexplained episodes of bleeding that have normal platelet numbers and a normal coagulation (clotting) profile are candidates for specific von Willebrand's factor testing.
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Von Willebrand's disease (vWD) is the most common inherited bleeding disorder of both humans and dogs. It is caused by a deficiency in the amount of a specific protein needed to help platelets (the blood cells used in clotting) stick together and form clots to seal broken blood vessels. The deficient protein is called von Willebrand factor (vWF).
Von Willebrand disease (vWD) is an inherited bleeding disorder resulting from a lack or reduced level of a normal blood clotting protein called von Willebrand factor (vWF). Disease presentation varies from asymptomatic to spontaneous hemorrhaging and prolonged bleeding after injury, surgery, or giving birth.
Testing Tips. Genetic testing of the VWF gene will reliably determine whether a dog is a genetic Carrier of von Willebrand disease I. Von Willebrand disease I is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease.
- chr27:38951839-38951839: G>A
- Autosomal Recessive
Testing for von Willebrand Disease in Dogs. There are only a few ways to test for von Willebrand disease in dogs. One way is called a buccal mucosal bleeding time test (BMBT). For this test, the veterinarian uses a small instrument to create a quick, sharp cut in the gums. From this they determine the length of time it takes for the blood to clot.