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  2. The most common, Type 1, occurs in dogs with low von Willebrand factor and results in mild to moderate signs. Dogs with Type 2 also have a low amount of the factor but have moderate to severe signs. The factor is absent in dogs with Type 3, which is most frequently seen in Shetland Sheepdogs and Scottish Terriers. Signs include bleeding of the gums, nosebleeds, and blood in the urine. Some puppies may bleed excessively only after injection or surgery. Signs of von Willebrand disease are ...

    • CBD Oil. Whether your dog has an injury or ongoing joint pain, studies show a good full spectrum CBD Oil can help … without aspirin’s side effects. CBD is a natural anti-inflammatory.
    • Turmeric. Turmeric can lower inflammation as well as ease pain and stiffness. So it’s a great choice if your dog has arthritis or other chronic pain. Turmeric’s active ingredient is called curcumin.
    • Boswellia (Boswellia serrata) If your dog has arthritis, Boswellia, or frankincense, is a good herb to try. Its phytochemicals help control inflammation.
    • Devil’s Claw (Harpagophytum procumbens) Devil’s claw is an African plant that’s an effective anti-inflammatory and analgesic. Devil’s Claw has been quite well researched.
    • Canine Cryoprecipitate Indications and Usage
    • Administration
    • Dosage
    • Rehydration
    • Contraindications
    • Warnings and Precautions
    • Adverse Reactions
    • Description
    • Storage Conditions

    Canine cryoprecipitate, lyophilized, is indicated for the treatment of inherited coagulopathies and von Willebrand’s crisis or prevention. Cryoprecipitate can also be used as a topical hemostatic in surgery or dental procedures. Administration of this product is a temporary means of support and not intended to permanently alleviate clinical signs o...

    Canine cryoprecipitate is recommended for intravascular administration through either a Hemo-Nate (or equivalent) filter or standard blood administration set. Topical application is recommended to control bleeding during surgery or dental procedures. This solution may be administered in conjunction with or combined with whole blood, pRBCs, plasma, ...

    One vial of lyophilized cryoprecipitate has an approximate minimum equivalency to a 250-300 milliliter unit of fresh frozen plasma (FFP). There is no research confirmed standard dosage for cryoprecipitate but the current literature recommends an empiric dosage of 1 unit of cryoprecipitate obtained from a 250 ml bag of FFP for each 10-12 kilograms o...

    Product should sit at room temperature for 5-10 minutes before adding diluent. Do not use needles larger than 20 GA as septum coring may result. Canine cryoprecipitate, lyophilized, should be rehydrated by adding 70ml of 0.9% sterile saline. Mix by swirling and gentle inversion of the product until all powder is rehydrated. Once diluent is added, t...

    A history of anaphylaxis to plasma containing products is a contraindication for use. If necessary, minor crossmatch should be performed to support compatibility.

    This product must be used within twenty-four (24) hours of rehydration to assure stability of the coagulation factors, particularly factor VIII. Due to the delicate nature of clotting factors it is recommended that this product be rehydrated immediately before use. Allowing it to sit in a rehydrated state, over time, will result in decreased potenc...

    Potential reactions to canine cryoprecipitate in recipient dogs may include nausea, peripheral vasodilation and urticaria. Individual anaphylactic reactions cannot be ruled out but are considered extremely rare.

    Canine cryoprecipitate, lyophilized, is made from a controlled thaw of source pooled fresh frozen plasma from active donors in the ABRI donor population. It is a sterile, nonpyrogenic white to pale amber powder. It contains a concentration of the cold insoluble portion of plasma containing approximately 50% Factor VIII, 20% fibrinogen and some Fact...

    This product is shipped refrigerated or frozen. Canine cryoprecipitate should be stored at 4-6°C (refrigerated) until use. Product, before rehydration, is stable for 18 months as labeled. Refrigerated storage of rehydrated product is required if the product will not be administered within two hours. Rehydrated product should be discarded after 24 h...

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  3. Any immunosuppressive dose of glucocorticosteroids may induce serious side effects including gastrointestinal ulcers, thromboembolism, iatrogenic hyperadrenocorticism, and bacterial infections. Interestingly there is one additional immunosuppressive agent that is considered highly effective and relatively safe in the initial management of severe acute ITP.

  4. Brachycephalic obstructive airway syndrome (BOAS) is a disorder of breathing difficulty in short-snouted and “bully” breeds. Breeds with the highest prevalence include Bulldogs, French Bulldogs, and Pugs. BOAS occurs because of a mismatch in the proportions of the skull and soft tissue in the nose and pharynx.

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