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  1. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See Prescribing Information. ZPC-01080R6 | ZPR-00175R2. Protect Your Pup and Earn up to $80 in Rewards.

  2. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against: *Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, Rhipicephalus sanguineus. †Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria ...

  3. Simparica Trio is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Simparica Trio does the work of two or three parasiticides in a single chewable by combining three proven ingredients. It’s available with a veterinarian prescription and is backed by a 100% ...

  4. 10. 12. 300. 30. Important Safety Information: Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly ...

  5. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in ...

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