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Mar 17, 2022 · Clinical manifestations of sodium nitrite poisoning include peripheral cyanosis, headache, skin flushing, altered skin color, orthostatic hypotension with reflex tachycardia, hypoxia, altered mental status, nausea, vomiting, diarrhea, loss of consciousness, dysrhythmias, and death. 5
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Oct 27, 2022 · Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death.
The Bottom Line. Nitrates and nitrites are abundant in the environment and are found in medicines and products in the home. Overexposure to nitrates and nitrites can lead to a condition called methemoglobinemia in which the body is deprived of oxygen, causing a blue-gray discoloration of the skin. The Full Story.
The most sensitive and widely-recognized toxic effect of nitrate and nitrite is that of nitrite-induced methemoglobinemia in which nitrite (ingested as nitrite, formed via bacterial reduction of ingested nitrate, and/or produced as an endogenous product of the nitric oxide oxidation) reacts with ferrous (Fe 2+) hemoglobin (which transports ...
Acute acquired methemoglobinemia is the most important adverse health effect caused by excessive nitrate/nitrite exposure. The known toxic effects from nitrate exposure result from the conversion of nitrate to nitrite.
Feb 1, 2024 · Documented cases of sodium nitrite toxicity are almost exclusively caused by accidental ingestion; however, self-poisoning with sodium nitrite represents an increasing trend in nitrate-related deaths.
Nov 5, 2020 · Metrics. Reprints & Permissions. Read this article. Sodium nitrite is a powerful oxidizing agent that causes hypotension and limits oxygen transport and delivery in the body through the formation of methemoglobin. Clinical manifestations can include cyanosis, hypoxia, altered consciousness, dysrhythmias, and death.
