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Nitroprusside is an inorganic compound with the chemical formula Na 2 [Fe(CN) 5 NO], usually encountered as the dihydrate, Na 2 [Fe(CN) 5 NO]·2H 2 O. This red-colored sodium salt dissolves in water or ethanol to give solutions containing the free complex dianion [Fe(CN) 5 NO] 2−.
- C₅FeN₆Na₂O
- AU: C
- By haemoglobin being converted to cyanmethaemoglobin and cyanide ions
- Nipride, Nitropress, others
Oct 15, 2020 · Mechanism of Action. Sodium nitroprusside is a water-soluble salt comprised of ferrous iron complexed with nitric oxide (NO) and five cyanide ions. Acting as a prodrug, SNP reacts with sulfhydryl groups on erythrocytes (as well as albumin and other proteins) to produce nitric oxide (NO).
Sodium Nitroprusside | C5H4FeN6Na2O3 | CID 73415791 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Sodium nitroprusside [Fe (CN)5 NO] 2− 2Na + (SNP) has been known since 1850 [495]. It is of course neither a nitro compound nor a prusside but the trivial name has been widely adopted. Its structure has been well established from UV, IR, Mössbauer and crystallographic studies.
Introduction and History. Sodium nitroprusside (SNP) is a well-known arterial and venous vasodilator used in clinical practice to lower blood pressure. Initially discovered in 1849 by Playfair, [ 1] SNP's first reported use in a patient was by Johnson in 1922. [ 2] .
- Daniel G Hottinger, David S Beebe, Thomas Kozhimannil, Richard C Prielipp, Kumar G Belani
- 10.4103/0970-9185.142799
- 2014
- Oct-Dec 2014
Jun 25, 2017 · Sodium nitroprusside (SNP) entered into clinical practice in 1955 and gained popularity as a vasodilator for hypertensive emergencies because of its rapid onset of action and short duration, which allowed for bedside titration to the desired effect [1].
Chemistry and Pathophysiology. The structure of SNP (Fig. 1) explains why desired vasodilation and cyanide toxicity may result from its use. SNP contains about 50 % 1. cyanide by weight. Early investigators attributed SNP ’s in vivo decomposition to hydrocyanic acid (HCN) to a reaction with oxyhemoglobin.
