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Legal status. In Wikidata. Statins (or HMG-CoA reductase inhibitors) are a class of medications that reduce illness and mortality in people who are at high risk of cardiovascular disease. They are the most commonly prescribed cholesterol-lowering drugs.
- HMG-CoA reductase inhibitors
- HMG-CoA reductase
- CE Sunt Statinele?
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Statinele sunt compusi biologici sau de sinteza care au proprietatea de a inhiba o enzima cu rol important in biosinteza colesterolului, si anume 3-hidroxi-3-metilglutaril-CoA-reductaza. Prin aceasta functie, tratamentul cu statine ajuta la reducerea biosintezei endogene de colesterol, cu scaderea concomitenta a concentratiilor anormale de colester...
Statinele au rolul de a reduce nivelul de colesterol din organism si de a reduce sinteza de novoa colesterolului, prin inhibarea unei enzime esentiale implicate in acest proces. Tratamentul cu statine se prescrie persoanelor cu hipercolesterolemie.
Indicatiile aprobate pentru administrarea acestor medicamente includ cazurile de: 1. hiperlipidemie si dislipidemie mixta; 2. hipertrigliceridemie; 3. disbetalipoproteinemie primara; 4. ateroscleroza; 5. preventia bolii cardiovasculare aterosclerotice; 6. copii si adulti cu hipercolesterolemie familiala. Bineinteles, medicul poate recomanda tratame...
Tratamentele cu statine sunt deosebit de eficiente, intrucat reduc riscul cardiovascular, scazand si mortalitatea asociata acestor afectiuni. Cu toate acestea, deoarece inhiba etapa de biosinteza a colesterolului in care se produce compusul intermediar numit „malavonat”, terapia cu statine influenteaza si functia endoteliala, raspunsul inflamator s...
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Statinele si administrarea acestora, intre indicatii si precautii. Statinele au un rol important in tratamentul bolilor cardiovasculare, atat in profilaxia primara cat si in cea secundara, fiind in general medicamente bine tolerate clinic. Administrarea lor se poate asocia cu anumite efecte secundare, de cele mai multe ori tranzitorii.
Apr 17, 2023 · Statins are used to: Lower high cholesterol (also known as hyperlipidemia or dyslipidemia ). Statins are most effective at lowering LDL-cholesterol (this is commonly referred to as “bad” cholesterol) Reduce a person’s risk of having a heart attack or stroke or developing angina.
Nov 29, 2023 · In fact, statins are the most prescribed drugs in the U.S. But you may have questions. You may be wondering about side effects of statins, types of statins, how statins work, and what your doctor may prescribe instead of statins to help lower your cholesterol.
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Feb 5, 2023 · Statins are a selective, competitive inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, the enzyme responsible for converting HMG-CoA to mevalonate in the cholesterol synthesis pathway. By reducing hepatic cholesterol synthesis, an upregulation of LDL receptors and increased hepatic uptake of LDL-cholesterol from the circulation occurs.
Mar 6, 2024 · By Mayo Clinic Staff. Statins are drugs that can lower your cholesterol. They work by blocking a substance that your body needs to make cholesterol. Lowering cholesterol isn't the only benefit of taking a statin. These medicines also have been linked to a lower risk of heart disease and stroke.
