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Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. It is administered by injection into a vein or muscle.
Streptomyces is the largest genus of the Actinomycetota and is the type genus of the family Streptomycetaceae. [5] These are Gram-positive bacteria with high GC content [5] and are characterised by a complex secondary metabolism. [6] They produce over two-thirds of the clinically useful antibiotics of natural origin. [7]
Pharmacology Indication. Although streptomycin was the first antibiotic available for the treatment of mycobacterium tuberculosis, it is now largely a second line option due to resistance and toxicity. 2 Streptomycin may also be used to treat a variety of other infections caused by susceptible strains of aerobic bacteria where other less toxic agents are ineffective.
In enzymology, a streptomycin 3"-kinase ( EC 2.7.1.87) is an enzyme that catalyzes the chemical reaction. ATP + streptomycin ADP + streptomycin 3"-phosphate. Thus, the two substrates of this enzyme are ATP and streptomycin, whereas its two products are ADP and streptomycin 3''-phosphate . This enzyme belongs to the family of transferases ...
Puromycin is an aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, [1] that causes premature chain termination during translation taking place in the ribosome. Part of the molecule resembles the 3' end of the aminoacylated tRNA. It enters the A site and transfers to the growing chain, causing the formation of a ...
Streptomycin is an aminoglycosides and antitubercular antibiotic that is FDA approved for the treatment of Mycobacterium tuberculosis and Non-tuberculosis infections like plague, tularemia, Brucella, donovanosis, granuloma inguinale, chancroid, H. influenzae (in respiratory, endocardial, and meningeal infections -concomitantly with another ...
A broad- spectrum antibiotic is an antibiotic that acts on the two major bacterial groups, Gram-positive and Gram-negative, [1] or any antibiotic that acts against a wide range of disease-causing bacteria. [2] These medications are used when a bacterial infection is suspected but the group of bacteria is unknown (also called empiric therapy) or ...
