Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide.
Streptomycin is a amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class It has a role as an antimicrobial agent, an antimicrobial drug, an antibacterial drug, a protein synthesis inhibitor, a bacterial metabolite and an antifungal agrochemical.
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Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae. Over 500 species of Streptomyces bacteria have been described. As with the other Actinobacteria, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes ...
Streptomycin is a first-line bactericidal agent with a minimum inhibitory concentration (MIC) against M. tuberculosis of 8 µg/mL. Streptomycin is usually given by intramuscular (IM) injection at a dose of 15 mg/kg per day (up to 1 g per day) for the first 1 or 2 months of treatment.
Streptomycin, the first clinically useful drug discovered in the fight against tuberculosis, is an aminoglycoside that has to be given intramuscularly. Streptomycin penetrates cerebrospinal fluid and other remote tissues (e.g. prostate and eye) poorly. There is an immediate and a delayed pathway of excretion via the renal tract.
2. Streptomycin hydrochloride was dissolved in methanol containing 3 per cent. (by volume) of concentrated sulphuric acid. After several days at 25 "C. streptidine sulphate crystallised out12. 3. Streptomycin sulphate was hydrolysed with 4 parts of N sulphuric acid for 48 hours at 45°C. Streptidine sulphate separated in crystalline 4.