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In veterinary medicine, streptomycin is the first-line antibiotic for use against gram negative bacteria in large animals ( horses, cattle, sheep, etc.). It is commonly combined with procaine penicillin for intramuscular injection. [medical citation needed] Tularemia infections have been treated mostly with streptomycin.
Jul 4, 2023 · Streptomycin is the first discovered aminoglycoside antibiotic, originally isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis. It has additional activity against several aerobic gram-negative bacteria. This activity will discuss the indications, mechanism of action, and contraindications of using streptomycin ...
- Mitchell Waters, Prasanna Tadi
- 2023/07/04
General. Type: Aminoglycosides Dosage Forms: IM; Adult Dosing Infections, Bacterial. 1-2 g/day IM divided q6-12h Max: 2 g/day; Info: adjust dose based on serum levels
Streptomycin is an aminoglycoside antibiotic, and was the first of these to be discovered in 1943 by Albert Shatz. [1] [2] [3] The use of streptomycin involves the disruption of protein synthesis within the ribosome, preventing replication of bacteria. [4] It arises from the bacteria Streptomyces griseus and is majorly used in the treatment of ...
Streptomycin was discovered by Schatz, Bugie and Waksman (1944) in the culture media of certain strains of Streptomyces griseus. Great interest was aroused when it was found that this compound exhibited antibiotic activity against certain bacteria and particularly the organism responsible for tuberculosis.
streptomycin, antibiotic synthesized by the soil organism Streptomyces griseus. Streptomycin was discovered by American biochemists Selman Waksman, Albert Schatz, and Elizabeth Bugie in 1943. The drug acts by interfering with the ability of a microorganism to synthesize certain vital proteins. It was the first antimicrobial agent developed ...
Aug 30, 2017 · Streptomycin binds the 30S subunit of the bacterial ribosome, which terminates protein synthesis. The drug is excreted unchanged in the urine. 20‐40 mg/kg/day up to 1 gram a day is recommended for tuberculosis as well as severe bacterial infections. Streptomycin is administered by intramuscular injection only.
