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  1. › wiki › StreptomycinStreptomycin - Wikipedia

    Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. It is administered by injection into a vein or muscle. Common side effects include vertigo, vomiting, numbness of the face, fever, and rash. Use during pregnancy may resul

    • 84% to 88% IM (est.) 0% by mouth
    • Kidney
  2. Streptomycin is an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit.

    • C21H39N7O12
    • 19.6K
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    What kind of infections can streptomycin be used for?

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    • Uses
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    • Mechanism of Action
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    1. Infective endocarditis: An infection of the endocardium caused by enterococcus; used when the organism is not sensitive to gentamicin[medical citation needed] 2. Tuberculosis: Used in combination with other antibiotics. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. It is not the first-line treatment, except in medically under-served populations where the cost of more expensive treatments is prohibitive. It may be useful in cases where resi...


    Strep­to­mycin also is used as a pes­ti­cide, to com­bat the growth of bac­te­ria be­yond human ap­pli­ca­tions. Strep­to­mycin con­trols bac­te­r­ial dis­eases of cer­tain fruit, veg­eta­bles, seed, and or­na­men­tal crops. A major use is in the con­trol of fire­b­light on apple and pear trees. As in med­ical ap­pli­ca­tions, ex­ten­sive use can be as­so­ci­ated with the de­vel­op­ment of re­sis­tant strains. Strep­to­mycin could po­ten­tially be used to con­trol cyanobac­te­r­ial blooms in...

    Cell culture

    Strep­to­mycin, in com­bi­na­tion with peni­cillin, is used in a stan­dard an­tibi­otic cock­tail to pre­vent bac­te­r­ial in­fec­tion in cell culture.[medical citation needed]

    The most con­cern­ing side ef­fects, as with other amino­gly­co­sides, are kid­ney tox­i­c­ity and ear tox­i­c­ity. Tran­sient or per­ma­nent deaf­ness may re­sult. The vestibu­lar por­tion of cra­nial nerve VIII (the vestibu­lo­cochlear nerve) can be af­fected, re­sult­ing in tin­ni­tus, ver­tigo, ataxia, kid­ney tox­i­c­ity, and can po­ten­tially in­ter­fere with di­ag­no­sis of kid­ney malfunction. Com­mon side ef­fects in­clude ver­tigo, vom­it­ing, numb­ness of the face, fever, and rash. Fever and rashes may re­sult from per­sis­tent use.[citation needed] Use is not rec­om­mended dur­ing pregnancy. Con­gen­i­tal deaf­ness has been re­ported in chil­dren whose moth­ers re­ceived strep­to­mycin dur­ing pregnancy. Use ap­pears to be okay while breast­feed­ing. It is not rec­om­mended in peo­ple with myas­the­nia gravis.

    Strep­to­mycin is a pro­tein syn­the­sis in­hibitor. It binds to the small 16S rRNA of the 30S sub­unit of the bac­te­r­ial ri­bo­some ir­re­versibly, in­ter­fer­ing with the bind­ing of formyl-me­thionyl-tRNA to the 30S subunit. This leads to codon mis­read­ing, even­tual in­hi­bi­tion of pro­tein syn­the­sis and ul­ti­mately death of mi­cro­bial cells through mech­a­nisms that are still not un­der­stood. Spec­u­la­tion on this mech­a­nism in­di­cates that the bind­ing of the mol­e­cule to the 30S sub­unit in­ter­feres with 50S sub­unit as­so­ci­a­tion with the mRNA strand. This re­sults in an un­sta­ble ri­bo­so­mal-mRNA com­plex, lead­ing to a frameshift mu­ta­tion and de­fec­tive pro­tein syn­the­sis; lead­ing to cell death. Hu­mans have ri­bo­somes which are struc­turally dif­fer­ent from those in bac­te­ria, so the drug does not have this ef­fect in human cells. At low con­cen­tra­tions, how­ever, strep­to­mycin only in­hibits growth of the bac­te­ria by in­duc­ing prokary­oti...

    Strep­to­mycin was first iso­lated on Oc­to­ber 19, 1943, by Al­bert Schatz, a PhD stu­dent in the lab­o­ra­tory of Sel­man Abra­ham Waks­man at Rut­gers Uni­ver­sity in a re­search pro­ject funded by Merck and Co. Waks­man and his lab­o­ra­tory staff dis­cov­ered sev­eral an­tibi­otics, in­clud­ing actin­o­mycin, clavacin, strep­tothricin, strep­to­mycin, gri­sein, neomycin, fradicin, can­di­cidin, and can­didin. Of these, strep­to­mycin and neomycin found ex­ten­sive ap­pli­ca­tion in the treat­ment of nu­mer­ous in­fec­tious dis­eases. Strep­to­mycin was the first an­tibi­otic cure for tu­ber­cu­lo­sis (TB). In 1952 Waks­man was the re­cip­i­ent of the Nobel Prize in Phys­i­ol­ogy or Med­i­cine in recog­ni­tion "for his dis­cov­ery of strep­to­mycin, the first an­tibi­otic ac­tive against tuberculosis". Waks­man was later ac­cused of play­ing down the role of Schatz who did the work under his su­per­vi­sion, claim­ing that Eliz­a­beth Bugiehad a more im­por­tant role in its devel...

    Philip D'Arcy Hart– The British medical researcher and pioneer in tuberculosis treatment in the early twentieth century.

    "Notebooks Shed Light on an Antibiotic's Contested Discovery," The New York Times, June 12, 2012, by Peter Pringle
    Kingston, William (2004). "Streptomycin, Schatz v. Waksman, and the Balance of Credit for Discovery". Journal of the History of Medicine and Allied Sciences. 59 (3): 441–462. doi:10.1093/jhmas/jrh0...
    Mistiaen, Veronique (November 2, 2002). "Time, and the great healer". The Guardian.. The history behind the discovery of streptomycin.
  4. › wiki › StreptomycesStreptomyces - Wikipedia

    Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae. Over 500 species of Streptomyces bacteria have been described. As with the other Actinobacteria, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Streptomycetes are charact

    • Streptomyces, Waksman and Henrici 1943 (Approved Lists 1980)
    • Streptomycetaceae
  5. › DebanganaMoitra › streptomycinSTREPTOMYCIN - SlideShare

    May 16, 2017 · Streptomycin is highly resistant to the action of enzymes and other biological agents. • Streptomycin is relatively nontoxic to man. But after the use of streptomycin, reactions such as presence of pain, irritation, headache, fever, blood pressure drop, disturbances in eighth cranial nerve, skin eruption, albumin in urine may take place. 10.

  6. May 03, 2020 · Media in category "Streptomycin". The following 10 files are in this category, out of 10 total. Core structure of pen-strep.png 500 × 500; 9 KB. Strep1.png 460 × 290; 34 KB. Streptomycin structure.png 883 × 593; 15 KB. Streptomycin-1ntb-xtal-3D-balls.png 1,100 × 789; 234 KB.

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