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Geena Davis

Mrs. Little

Hugh Laurie

Mr. Little

Jonathan Lipnicki

George Little

Brian Doyle-Murray

Cousin Edgar

Estelle Getty

Grandma Estelle

Julia Sweeney

Mrs. Keeper

Dabney Coleman

Dr. Beechwood

Michael J. Fox

Stuart Little

Nathan Lane

Snowbell

Chazz Palminteri

Smokey

Steve Zahn

Monty

Stan Freberg

Race Announcer

Jim Doughan

Lucky

Jeffrey Jones

Uncle Crenshaw