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What is substantia nigra?
What is the co-dependence between striatum and substantia nigra?
What is the role of substantia nigra neurons in Parkinson's syndrome?
2 days ago · Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the depletion of dopaminergic neurons in the substantia nigra pars compacta (SNc) 1.The SNc ...
12 hours ago · Dopamine (DA) signals originating from substantia nigra (SN) neurons are centrally involved in the regulation of motor and reward processing. DA signals behaviorally relevant events where reward outcomes differ from expectations (reward prediction errors, RPEs). RPEs play a crucial role in learning optimal courses of action and in determining response vigor when an agent expects rewards ...
1 day ago · Next-generation gene therapy demonstrates best-in-class potential with majority of neurons transduced in substantia nigra and high levels of GCase supplementation after single IV infusion Broad GCase elevation achieved in NHPs, while significantly detargeting the liver compared with AAV9, with no clinical pathology, immunogenicity, or histopathology findings, including in DRGs Wholly owned ...
4 days ago · The nerve fibers associated with eye movement project to the superior colliculus (SC) through the basal ganglia substantia nigra pars reticulata, which exerts a sustained inhibitory effect on the SC, and the abnormal saccades of PD may be associated with the weakened inhibition of SC by the apoptosis of dopaminergic neurons in the substantia ...
4 days ago · substantia nigra pars compacta (SNpc) region and striatal regions were sliced using a cryostat and . then embedded onto slides for further investigations. 20 μm rat brain cryosections, were blocked .
3 days ago · The disease burden of PD in China has consistently risen over the past three decades, particularly among elderly men. The increasing causative factors and population aging highlight the need for enhancing public health intervention and resource allocation, especially in etiological research, early diagnosis, preventive strategies, and region-specific management for PD.
4 days ago · Cognitive impairment in Parkinson’s disease (PD) is associated with changes in the brain anatomical structures. The objective of this study, is to identify the atrophy patterns based on the severity of cognitive decline and evaluate the disease progression. In this study, gray matter alterations are analysed in 135 PD subjects under 3 cognitive domains (91 Cognitively normal PD (NC-PD), 25 ...
