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The substantia nigra ( SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement. Substantia nigra is Latin for "black substance", reflecting the fact that parts of the substantia nigra appear darker than neighboring areas due to high levels of neuromelanin in dopaminergic neurons. [1] .
The substantia nigra location is between the midbrain and the diencephalon, a brain structure that connects the midbrain to the forebrain. Conventionally, the substantia nigra is...
Dec 8, 2023 · The Substantia Nigra, Latin for “black substance,” is aptly named for its dark coloration, a result of high levels of neuromelanin in dopaminergic neurons. This structure is situated in the midbrain, an area that connects the forebrain and hindbrain, playing a pivotal role in motor control and a host of other functions.
Aug 21, 2017 · SN neurons can be divided into three tiers based on their staining, morphology, and connectivity with the striatum ( Haber, 2014; Haber and Knutson, 2010 ): moving from a dorso-medial to ventro-lateral location in midbrain, dopamine neurons project to limbic, associative and then motor striatum.
Quick Facts. The substantia nigra is located in the midbrain and plays an important role in reward, addiction and movement. The substantia nigra appears darker than neighboring areas, due to high levels of melanin in dopaminergic neurons. Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra.
Located within the midbrain posterior to the crus cerebri fibers of the cerebral peduncle, the substantia nigra can be functionally and morphologically divided into two regions, Pars compacta (SNpc): Most of the dopamine neurones of the brain are found in either the substantia nigra or the ventral tegmental area, which is located adjacent to ...
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