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Jun 8, 2021 · Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. There are various imaging markers for Parkinson disease. Recent advances in MRI have enabled elucidation of the underlying pathophysiologic changes in the nigral structure. This has contributed to accurate and early diagnosis and has improved disease progression monitoring. This article aims ...
- Shy-Drager Syndrome
The Shy-Drager syndrome (SDS) is a form of progressive...
- Quantitative Mr Imaging of Brain Iron
Purpose To investigate the relationship between transverse...
- Utility of Nigrosome 1 With 3-T Imaging
The substantia nigra of the human brain. II. Patterns of...
- Loss of Substantia Nigra Hyperintensity at 3.0-T Mr Imaging in Idiopathic REM Sleep Behavior Disorder
The substantia nigra of the human brain. II. Patterns of...
- Shy-Drager Syndrome
Sep 18, 2020 · Evidence is thus converging from neuropathology and neuroimaging for location-specific changes in the substantia nigra during Parkinson’s disease progression. Another key finding from Biondetti et al. is that the severity of motor, cognitive and limbic symptoms correlated with the neuromelanin signal in spatially-specific regions of the ...
- David E Vaillancourt, Trina Mitchell
- 10.1093/brain/awaa252
- 2020
- Brain. 2020 Sep; 143(9): 2628-2630.
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Oct 24, 2022 · The substantia nigra (SN) is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. Projections from the SN to the putamen, called the nigrostriatal pathway, are critically involved in the motor deficits observed in Parkinson disease.[1] These dopaminergic neural projections leave the SN via the medial ...
- James Sonne, Vamsi Reddy, Morris R. Beato
- 2022/10/24
- 2020
Jun 9, 2021 · Abstract. Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by motor and non-motor symptoms due to the degeneration of the pars compacta of the substantia nigra (SNc) with dopaminergic denervation of the striatum. Although the diagnosis of PD is principally based on a clinical assessment, great efforts have ...
- Paola Feraco, Cesare Gagliardo, Giuseppe La Tona, Eleonora Bruno, Costanza D'angelo, Maurizio Marral...
- 10.3390/brainsci11060769
- 2021
- Brain Sci. 2021 Jun; 11(6): 769.
Aug 21, 2020 · The main hallmark of Parkinson’s disease (PD), the most common progressive neurodegenerative movement disorder, is the selective loss of dopaminergic neurons (DaNs) in the substantia nigra (SN).
- Devika Agarwal, Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Tara M. Caffrey, Jim...
- 2020
May 5, 2022 · Degeneration of dopaminergic neurons in the substantia nigra is a pathological hallmark of Parkinson’s disease (PD). However, not all dopamine-producing neurons degenerate. Kamath, Abdulraouf et ...
This article aims to review recent developments in nigral imaging for Parkinson disease and other parkinsonian syndromes, including nigro-some imaging, neuromelanin imaging, quantitative iron mapping, and difusion-tensor imaging. In particular, this article examines nigrosome imaging using 7-T MRI and 3-T susceptibility-weighted imaging.
