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Nov 27, 2022 · Antiviral nucleic acid polymers (NAPs) can directly inhibit viral entry or replication by binding to the virus particle, its building blocks, or RNA/DNA replication intermediates (Fig. 1 f). Several NAPs are under development for treatment of hepatitis C, influenza virus, norovirus, HSV, and HIV infections [ 34 ].
- Targeting Virus Replication
- Antiviral Agents
- Broad-Spectrum Antivirals
- Combinations of Antiviral Agents
- Antivirals Against Sars-Cov-2 Infection
Most viruses are recognized as hormones, cytokines or nutrient sources by one or more receptors on host cell surface. This mimicry strategy allows viruses to attach to specific cells, cross the plasma membrane barrier, enter the cell, and access essential cellular machineries . Inside the cells, host or viral polymerases amplify viral genomes throu...
Antivirals can be divided based on the targets which can be either host or viral factors. Virus-directed agents bind viral proteins or nucleic acids involved in viral entry, transcription, replication of the viral genome, assembly, and release of infectious viral particles. Host-directed antivirals modulate the activity of host factors and pathways...
Antivirals can target one or more viruses. Agents that inhibit the replication of many viruses are called broad-spectrum antivirals (BSAs). BSAs that inhibit the replication of viruses from the same or different viral families are called intra- or inter-family antivirals, respectively (Supplementary data, Fig. 2). For example, IFN-alpha, IFN-beta, ...
To target multiple viruses and mitigate the development of antiviral drug resistance, several antivirals can be administrated simultaneously (Supplementary data) [10, 46, 47]. Synergistic antiviral cocktails contain lower concentrations of agents. Such cocktails may reduce the side effects associated with high doses of monotherapies. The AntiviralC...
Immediately after the SARS-CoV-2 was isolated the virus interactions with host cells were analyzed using systems biology approaches . Researchers identified the critical nodes of the molecular networks (interactomes). Transcriptomics/RNA-sequencing was a key method to accurately detect changes in virus-host interactomes during virus evolution . Sev...
Apr 11, 2024 · HbeAg adalah antigen e virus hepatitis B. Keberadaan HbeAg dalam darah menunjukkan bahwa virus hepatitis B sedang aktif mereplikasi diri dan seseorang dalam tahap infeksi yang berpotensi menularkan virus lebih mudah. HbeAg juga dapat memberikan petunjuk tentang tingkat reproduktivitas virus dan keparahan infeksi. 3.
Nov 27, 2022 · This work identifies new synergistic combinations against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), echovirus 1 (EV1), hepatitis C virus (HCV) and human immunodeficiency virus 1 (HIV-1) in vitro and indicates that synergy is achieved when a virus-directed antiviral is combined with another virus- or host-directed agent.
Oct 31, 2007 · In bacteria, the 30S ribosomal subunit, assisted by initiation factors (IF) 1, 2 and 3 and fMet-tRNA fMet, recognizes the translation initiation region (TIR) of the mRNA. This event is followed by binding of the 50S ribosomal subunit and release of the initiation factors [ 1 ].
- Vladimir Vimberg, Age Tats, Maido Remm, Tanel Tenson
- 2007
Apr 13, 1990 · Purchasers who saw "360°" on a Reebok shoe before ever seeing a Tanel shoe might conclude that Tanel was in some way affiliated with Reebok, that plaintiff's shoes were made by Reebok, or that Tanel in using "360°" was imitating Reebok.
See the popularity of the baby name Tanel over time, plus its meaning, origin, common sibling names, and more in BabyCenter's Baby Names tool.
