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  2. Jan 26, 2024 · Medicines such as gabapentin (Neurontin, Gralise), gabapentin enacarbil (Horizant) and pregabalin (Lyrica), work for some people with RLS. Muscle relaxants and sleep medicines. These medicines help you sleep better at night, but they don't eliminate the leg sensations. They also may cause daytime drowsiness.

    • Laura Persons
    • Ruling out potential causes. Your first step in addressing RLS should be to figure out if something is causing it. While RLS can be related to things that are largely out of your control, such as genetics or pregnancy, other possible factors can be addressed.
    • Healthy sleep habits. Having good sleep habits is advisable for anyone, but perhaps especially for people who have trouble sleeping, such as those with RLS.
    • Iron and vitamin supplements. Iron deficiency is thought to be one of the main causes of RLS. Several studies have shown that iron supplements can help ease RLS symptoms (1, 3).
    • Exercise. Exercise can help you feel better if you have RLS. The National Institutes of Health states that moderate exercise may help ease mild RLS symptoms (3).
  3. Jan 16, 2024 · Restless legs syndrome treatment aims to reduce discomfort from symptoms and improve sleep quality. While RLS symptoms may never fully go away , they can be significantly improved through a combination of lifestyle changes, vitamin and mineral supplements, medical devices, and medication.

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  4. Dopamine agonists, alpha 2 -delta calcium channel ligands, and opioids are effective therapies, but understanding of the mechanisms through which they work will depend on better elucidation of the underlying disease pathogenesis.

  5. This causes: The need to move the legs for temporary relief of symptoms by: Stretching or bending. Rubbing the legs. Tossing or turning in bed. Getting up and pacing. Worsening symptoms when lying down, especially when trying to fall asleep at night, or during other forms of inactivity, including just sitting.

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