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  1. Jan 28, 2023 · Diagnosis. Medical and travel history. Your health care provider may suspect typhoid fever based on your symptoms, and your medical and travel history. The diagnosis is often confirmed by growing the Salmonella enterica serotype typhi in a sample of your body fluid or tissue. Body fluid or tissue culture.

  2. Typhoid fever is a serious infection caused by a type of bacteria. It is more common in Africa, Latin America, and Asia (especially in Southeast Asia), but less so in the U.S. Most cases in this country are in people who got the disease while traveling outside of the U.S.

  3. Key Points. Typhoid fever is a systemic disease caused by the gram-negative bacterium Salmonella enterica serotype Typhi (S. (See also Overview of Salmonella Infections.) In the US, typhoid is uncommon and occurs mainly among US travelers returning from endemic regions. Worldwide, about 11 to 21 million cases occur each year (1). General reference.

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