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The VTA/NAcc reward circuit. Ventral tegmental area (VTA) contains cell bodies of dopaminergic neurons projecting to the nucleus accumbens, amygdala, hippocampus, and prefrontal cortex. Defined as the mesocorticolimbic dopamine system (Albanese and Minciacchi, 1983 ), these neurons are critically implicated in brain mechanisms of reward ...
Oct 18, 2019 · The core and the shell of the NAc both receive afferent input from the ventral tegmental area (Li et al., 2018). However, the core receives projections primarily from the lateral region of the ventral tegmental area, whereas the shell receives projections primarily from the medial region of the ventral tegmental area (Li et al., 2018).
Apr 27, 2022 · In this review, we present the most recent evidence for the ventral tegmental area (VTA) and nucleus accumbens (NAc) to serve as extra-SCN oscillators and highlight studies that illustrate the functional significance of the VTA's and NAc's inherent circadian properties as they relate to reward-processing, drug abuse, and vulnerability to ...
Jul 8, 2021 · The ventral tegmental area and the nucleus accumbens are the two main areas where any licit or illicit drug acts cause the addiction. When an individual consumes a drug, dopamine is released from the VTA, passing through its pathway into the nucleus accumbens and further into other parts, releasing pleasure.
Aug 12, 2021 · The long-range GABAergic input from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) is relatively understudied, and therefore its role in reward processing has remained unknown. In ...
Apr 26, 2022 · (B) The ventral tegmental area (VTA) and nucleus accumbens (NAc) circuit is the key reward pathway of the brain. Rewarding stimuli primarily stimulate dopamine (DA) neurons in the VTA to release DA into the NAc, driving medium spiny neuron (MSN) activity and subsequent reward-seeking behaviors.
The ventral tegmental area, or VTA, is in the midbrain, situated adjacent to the substantia nigra. Although it contains several different types of neurons, it is primarily characterized by its dopaminergic neurons, which project from the VTA throughout the brain. The VTA is considered an integral part of a network of structures, together known ...
