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Apr 27, 2022 · (B) The ventral tegmental area (VTA) and nucleus accumbens (NAc) circuit is the key reward pathway of the brain. Rewarding stimuli primarily stimulate dopamine (DA) neurons in the VTA to release DA into the NAc, driving medium spiny neuron (MSN) activity and subsequent reward-seeking behaviors.
- Time of day differences in dopamine clearance in the rat medial ...
INTRODUCTION. Many drugs of abuse exert feelings of reward...
- Evidence and explanation for the involvement of the nucleus ...
The core and the shell of the NAc both receive afferent...
- The Brain’s Reward System in Health and Disease - PMC
The ventral striatum, including the nucleus accumbens...
- Time of day differences in dopamine clearance in the rat medial ...
The nucleus accumbens and the ventral tegmental area are the primary sites where addictive drugs act. The following are commonly considered to be addictive: cocaine, alcohol, opioids, nicotine, cannabinoids, amphetamine, and their analogs. These drugs alter the neuromodulatory influence of dopamine on the processing of reinforcement signals by ...
Oct 30, 2023 · The nucleus accumbens receives dopaminergic projections from the ventral tegmental area and substantia nigra of the midbrain. This connection forms part of a major dopaminergic pathway called the mesolimbic pathway (reward pathway), which connects the VTA with regions of the limbic system including the nucleus accumbens, hypothalamus, amygdala ...
- Medical Content
- 22 min
Jan 5, 2017 · a | Axon terminals from ventral tegmental area (VTA) glutamate neurons projecting to the nucleus accumbens (nAcc) contain vesicular glutamate transporter 2 (VGLUT2) 22, release glutamate 22,42 and ...
- Marisela Morales, Elyssa B. Margolis
- 2017
Apr 27, 2022 · In this review, we present the most recent evidence for the ventral tegmental area (VTA) and nucleus accumbens (NAc) to serve as extra-SCN oscillators and highlight studies that illustrate the functional significance of the VTA's and NAc's inherent circadian properties as they relate to reward-processing, drug abuse, and vulnerability to ...
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