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  1. Apr 27, 2022 · (B) The ventral tegmental area (VTA) and nucleus accumbens (NAc) circuit is the key reward pathway of the brain. Rewarding stimuli primarily stimulate dopamine (DA) neurons in the VTA to release DA into the NAc, driving medium spiny neuron (MSN) activity and subsequent reward-seeking behaviors.

  2. The nucleus accumbens and the ventral tegmental area are the primary sites where addictive drugs act. The following are commonly considered to be addictive: cocaine, alcohol, opioids, nicotine, cannabinoids, amphetamine, and their analogs. These drugs alter the neuromodulatory influence of dopamine on the processing of reinforcement signals by ...

    • Area tegmentalis ventralis
    • Midbrain
  3. Oct 30, 2023 · The nucleus accumbens receives dopaminergic projections from the ventral tegmental area and substantia nigra of the midbrain. This connection forms part of a major dopaminergic pathway called the mesolimbic pathway (reward pathway), which connects the VTA with regions of the limbic system including the nucleus accumbens, hypothalamus, amygdala ...

    • Medical Content
    • 22 min
  4. Jan 5, 2017 · a | Axon terminals from ventral tegmental area (VTA) glutamate neurons projecting to the nucleus accumbens (nAcc) contain vesicular glutamate transporter 2 (VGLUT2) 22, release glutamate 22,42 and ...

    • Marisela Morales, Elyssa B. Margolis
    • 2017
  5. Apr 27, 2022 · In this review, we present the most recent evidence for the ventral tegmental area (VTA) and nucleus accumbens (NAc) to serve as extra-SCN oscillators and highlight studies that illustrate the functional significance of the VTA's and NAc's inherent circadian properties as they relate to reward-processing, drug abuse, and vulnerability to ...

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