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  1. The nucleus accumbens and the ventral tegmental area are the primary sites where addictive drugs act. The following are commonly considered to be addictive: cocaine, alcohol, opioids, nicotine, cannabinoids, and amphetamine and its analogs. These drugs alter the neuromodulatory influence of dopamine on the processing of reinforcement signals by ...

  2. Oct 30, 2023 · The nucleus accumbens is part of a large group of subcortical nuclei collectively called the basal ganglia (basal nuclei). It lies in the rostral cerebral hemisphere, in the ventral forebrain. It was formerly called nucleus accumbens septi due to its close relation to the base of septum pellucidum.

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  3. Jul 8, 2021 · The ventral tegmental area gets knowledge from different areas of the brain that tell it about the essential human needs and desires and how they are fulfilled. VTA transfers this information towards another part of the brain called the nucleus accumbens using dopamine neurons as a messenger.

  4. Sep 14, 2023 · The nucleus accumbens is an area found in the ventral striatum that is strongly associated with motivation and reward and is part of complex circuits involving the amygdala and the hippocampus. The activation of the nucleus accumbens causes dopamine levels in this region to rise.

  5. Location: The nucleus accumbens core is part of the ventral striatum, located within the basal ganglia. Cell types: The core of the NAcc is made up mainly of medium spiny neurons containing mainly D1-type or D2-type dopamine receptors.

  6. May 20, 2022 · The VTA functional diversity is partly reflected by its cellular and circuit heterogeneities. The VTA is composed of ∼60% dopaminergic neurons (DA neurons), ∼35% GABAergic neurons (GABA neurons), and ∼5% glutamate neurons (glutamate neurons) (Nair-Roberts et al., 2008; Yamaguchi et al., 2015).

  7. Jan 5, 2017 · Ventral tegmental area (VTA) dopamine neurons (which we here define as those neurons that express the dopamine-producing enzyme tyrosine hydroxylase (TH) and release dopamine (Box 1) are...

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