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Key regions in the brain’s reward circuitry
- The ventral tegmental area (VTA) and nucleus accumbens (NAc) are key regions in the brain’s reward circuitry. The VTA is responsible for the release of dopamine, a neurotransmitter that plays a key role in reward processing. The NAc is a key target of dopamine signaling and is involved in the processing of reward -related information.
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The nucleus accumbens and the ventral tegmental area are the primary sites where addictive drugs act. The following are commonly considered to be addictive: cocaine, alcohol, opioids, nicotine, cannabinoids, amphetamine, and their analogs. These drugs alter the neuromodulatory influence of dopamine on the processing of reinforcement signals by ...
Oct 30, 2023 · The nucleus accumbens receives dopaminergic projections from the ventral tegmental area and substantia nigra of the midbrain. This connection forms part of a major dopaminergic pathway called the mesolimbic pathway (reward pathway), which connects the VTA with regions of the limbic system including the nucleus accumbens, hypothalamus, amygdala ...
- Medical Content
- 22 min
Apr 27, 2022 · (B) The ventral tegmental area (VTA) and nucleus accumbens (NAc) circuit is the key reward pathway of the brain. Rewarding stimuli primarily stimulate dopamine (DA) neurons in the VTA to release DA into the NAc, driving medium spiny neuron (MSN) activity and subsequent reward-seeking behaviors.
- 10.3389/fphys.2022.886704
- 2022
- Front Physiol. 2022; 13: 886704.
Sep 14, 2023 · The brain's reward system is a network of structures responsible for pleasure, motivation, and reinforcement learning. Central to this system are the Ventral Tegmental Area (VTA) and the Nucleus Accumbens (NAc). When a rewarding stimulus is perceived, dopamine is released from the VTA, acting on the NAc, leading to feelings of pleasure.
The nucleus accumbens ( NAc or NAcc; also known as the accumbens nucleus, or formerly as the nucleus accumbens septi, Latin for ' nucleus adjacent to the septum ') is a region in the basal forebrain rostral to the preoptic area of the hypothalamus. [1] . The nucleus accumbens and the olfactory tubercle collectively form the ventral striatum.
May 20, 2022 · The ventral tegmental area (VTA) is well known for regulating reward consumption, learning, memory, and addiction behaviors through mediating dopamine (DA) release in downstream regions. Other than DA neurons, the VTA is known to be heterogeneous and contains other types of neurons, including glutamate neurons.
- Jing Cai, Qingchun Tong
- Front Neural Circuits. 2022; 16: 867053.
- 10.3389/fncir.2022.867053
- 2022
Jan 5, 2017 · Abstract. Dopamine-releasing neurons of the ventral tegmental area (VTA) have central roles in reward-related and goal-directed behaviours. VTA dopamine-releasing neurons are heterogeneous in...
