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May 14, 2024 · von Willebrand disease (VWD) is an inherited bleeding disorder caused by the deficiency or dysfunction of von Willebrand factor (VWF). 1 Given the increased risk of bleeding, patients with VWD are advised to avoid aspirin, P2Y12 inhibitors, or anticoagulants.
5 days ago · von Willebrand disease (VWD) is the most frequent inherited bleeding disorder with an estimated symptomatic prevalence of 1 per 1,000 in the general population. VWD is characterized by defects in the quantity, quality, or multimeric structure of von Willebrand factor (VWF), a glycoprotein being hemostatically essential in circulation. It is classified into three principal types; Low VWF/type 1 ...
May 10, 2024 · These include inflammation, wound healing, angiogenesis, and bone metabolism. Finally, recent evidence supports the hypothesis that the non-hemostatic functions of VWF directly contribute to pathogenic mechanisms in a variety of diverse diseases including sepsis, malaria, sickle cell disease and liver disease.
Apr 26, 2024 · Background. Von Willebrand disease (VWD) is the most common inherited bleeding disorder, characterized by either partial or complete von Willebrand factor (VWF) deficiency or by the occurrence of VWF proteoforms of altered functionality.
6 days ago · 1 INTRODUCTION. People with a severe von Willebrand disease (VWD) bleeding phenotype experience frequent, prolonged and excessive mucocutaneous bleeding, such as epistaxis, gingival or gastrointestinal (GI) bleeding, heavy menstrual bleeding, postoperative bleeds and hemarthroses, that has a significant effect on their quality of life. 1-6 Unfortunately, successful treatment of GI bleeding has ...
May 2, 2024 · We identified 7 new genetic regions for factor VIII levels, 1 for von Willebrand factor levels, and 3 in a combined analysis. Silencing B3GNT2 and CD36 reduced factor VIII release in vitro . Silencing B3GNT2 , CD36 , and PDIA3 reduced von Willebrand factor release.
May 13, 2024 · Haemophilia is an international haematology journal facilitating worldwide exchange of research into the comprehensive care of haemophilia and blood disease. Spectrum, clinical characteristics and outcome of von Willebrand disease in Oman - Alkaabi - Haemophilia - Wiley Online Library
