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1 day ago · von Willebrand disease (VWD) is the most frequent inherited bleeding disorder with an estimated symptomatic prevalence of 1 per 1,000 in the general population. VWD is characterized by defects in the quantity, quality, or multimeric structure of von Willebrand factor (VWF), a glycoprotein being hemostatically essential in circulation. It is classified into three principal types; Low VWF/type 1 ...
May 6, 2024 · A novel ELISA method to detect cVWF will improve the understanding of the clinical role of plasmin-mediated VWF degradation and hold significant promise for gaining further insights into the clinical relevance of plasmin-mediated VWF proteolysis in several pathologies. PURPOSE OF REVIEW Von Willebrand factor (VWF) plays a pivotal role in primary hemostasis. A Disintegrin And Metalloproteinase ...
Apr 26, 2024 · This paper is only available as a PDF. To read, Please Download here. Abstract. Background. Von Willebrand disease (VWD) is the most common inherited bleeding disorder, characterized by either partial or complete von Willebrand factor (VWF) deficiency or by the occurrence of VWF proteoforms of altered functionality.
Apr 19, 2024 · VWF O-glycans critically influence VWF biosynthesis and trafficking into Weibel-Palade bodies in human endothelial cells. O-glycan inhibition leads to VWF A1 domain activation and formation of significantly smaller Weibel-Palade bodies. Von Willebrand factor (VWF) undergoes complex post-translational modification within endothelial cells (EC ...
May 10, 2024 · Research Article | May 10, 2024. Novel functions for Von Willebrand factor. Ferdows Atiq, James S. O'Donnell. Blood blood.2023021915. https://doi.org/10.1182/blood.2023021915. Article history. Split-Screen. Share. Tools. PDF. For many years, it has been known that VWF interacts with FVIII, collagen and platelets.
4 days ago · Haemophilia is an international haematology journal facilitating worldwide exchange of research into the comprehensive care of haemophilia and blood disease. Spectrum, clinical characteristics and outcome of von Willebrand disease in Oman - Alkaabi - Haemophilia - Wiley Online Library
May 2, 2024 · Novel risk loci for thrombotic factors. Share. Tools. We identified 7 new genetic regions for factor VIII levels, 1 for von Willebrand factor levels, and 3 in a combined analysis. Silencing B3GNT2 and CD36 reduced factor VIII release in vitro. Silencing B3GNT2, CD36, and PDIA3 reduced von Willebrand factor release.
