Search results
During her pregnancy, vWF:Ag, vWF:RCo, and FVIII:C levels increased, but not to normal pregnancy levels. Thrombocytopenia became apparent and progressively worsened, with platelet counts decreasing from 350,000/µL before her pregnancy to 31,000/µL at 35 weeks.
Increased age, pregnancy, exercise, and stress may cause von Willebrand factor levels in the blood to rise, which can make bleeding symptoms less frequent. This disease is caused by genetic changes in the VWF gene and can have different inheritance patterns. Von Willebrand disease is a bleeding disorder that slows the blood clotting process.
Von Willebrand Factor. Large, complex glycoprotein (1000-20,000 KDa) essential for normal haemostasis. Half-life: 12 hours. VWF gene located on short arm of Chromosome 12. (Note: There is a pseudogene on Ch. 22 —> complicates interpretation of genetic testing!) Synthesized in:
Dec 27, 2023 · Von Willebrand disease is an inherited blood disorder that causes frequent or prolonged bleeding. ... It's a good idea to talk to a specialist throughout your pregnancy to carefully monitor your ...
James AH, Jamison MG. Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost. 2007;5(6):1165-1169. James AH, Konkle BA, Kouides P, et al. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.
Abstract. Background: von Willebrand disease type 3, is an extremely rare condition. It can be severe and potentially life-threatening, particularly in pregnant women during labor and subsequently during early puerperium. Due to its rarity, there is no optimal treatment/management during pregnancy. Case: We describe two cases of pregnant women ...
Apr 7, 2023 · Thrombotic thrombocytopenic purpura (TTP) is a type of microangiopathic hemolytic anemia that classically has been characterized by the pentad of fever, thrombocytopenia, hemolytic anemia, renal dysfunction, and neurologic dysfunction. TTP results from either a congenital or acquired decrease/absence of the von Willebrand factor-cleaving protease ADAMTS13 (a disintegrin and metalloproteinase ...
