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How is von Willebrand disease diagnosed?
Is von Willebrand disease hereditary?
What does von Willebrand disease mean?
Psuedo von Willebrand disease in pregnancy can be confused with a number of other differential diagnoses, such as gestational thrombocutopenia, idiopathatic thrombocytopenia, thrombotic thrombocytopenic purpura and pre-eclampsia; all need consideration during investigations even in a case such as this where the diagnosis of platelet type von Willebrand disease was known before pregnancy.
- Neetu Grover, Vincent Boama, Munazzah Rifat Chou
May 01, 2017 · A 37-year-old woman 28 weeks into her first pregnancy is referred to hematology clinic given a history of von Willebrand disease (vWD) diagnosed during her teenage years, after presenting with excessive menstrual bleeding requiring oral iron supplementation.
- Caroline Berube, Brian Dietrich
Von Willebrand disease (VWD) occurs with equal frequency among men and women, affecting up to 1% of the general population.1,2However, women are more likely to experience symptoms of VWD because of...
In a CDC survey of women with VWD: [Read articleexternal icon] 1. There was an average of 16 years between the onset of their bleeding symptoms and diagnosis of a bleeding disorder. 2. Women reported an average of 6 bleeding symptoms before a diagnosis of VWD was made. Common symptoms included menorrhagia, bruising, nosebleeds, and bleeding from surgery, injury, and delivery. Menorrhagia was the most commonly reported symptom. 3. To obtain the diagnosis of VWD, tests were carried out on average twice (range 1–20 times). 4. 38% of women reported that they were first diagnosed by a Hemophilia Treatment Center (HTC) doctor. Among women diagnosed by a provider other than an HTC doctor, 42% were diagnosed by a hematologist, 28% by an internist or a family doctor and 19% by a gynecologist.
In a CDC study of 102 women with all types of VWD compared to 88 controls: [Read articleexternal icon] 1. The most commonly reported bleeding symptoms among women with VWD were: 1.1. Heavy menstrual bleeding (95%) 1.2. Bleeding after minor injuries (92%) 1.3. Excessive gum bleeding (76%) 2. 74% of women with VWD reported excessive bleeding from several sites (e.g. nose, gum and uterus) or following several procedures or injuries (e.g. dental, surgical, childbirth and minor injury) compared to 6% of controls. 3. 41% of women with VWD reported a diagnosis of migraine headaches compared with 13% of controls. 4. 37% of women with VWD reported a diagnosis of arthritis compared with 15% of controls. 5. 37% of women with VWD compared with 10% of controls indicated that their menstrual period limited routine work, social activities and had a negative effect on life. 6. More women with VWD than controls in this study had undergone hysterectomy (25% vs. 9%). In studies of 42 men and 38 women...Rodeghiero F, Castaman G, Dini E. Epidemiological investigation of the prevalence of von Willebrand’s disease. Blood. 1987 Feb;69(2):454-9.Werner EJ, Broxson EH, Tucker EL, et al. Prevalence of von Willebrand disease in children: a multiethnic study. J Pediatr 1993 Dec; 123(6): 893-8.Ragni MV, FA Bontempo, C Hassett. Von Willebrand disease and bleeding in women. Haemophilia 1999; 5:313-317.Ziv O, Ragni MV. Bleeding manifestations in males with von Willebrand disease. Haemophilia 2004; 10:162-8.
May 20, 2019 · Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in haemophilia A, may be variably reduced in VWD patients.
- Giancarlo Castaman, Paula D James
To cite this article: Kujovich JL. von Willebrand disease and pregnancy. J Thromb Haemost 2005; 3: 246–53. Von Willebrand disease (VWD) is the most common inherited bleeding disorder, found in approximately 1% of the general population, without ethnic differences [1,2]. VWD is the result of a deﬁciency or defect in von Willebrand factor ...
- J. L. Kujovich
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Mild forms of von Willebrand disease can be difficult to diagnose because bleeding is common, and, for most people, doesn't indicate a disease. However, if your doctor suspects you have a bleeding disorder, he or she might refer you to a blood disorders specialist (hematologist). To evaluate you for von Willebrand disease, your doctor will likely ask you detailed questions about your medical history and check for bruises or other signs of recent bleeding. Your doctor will also likely recommend the following blood tests: 1. Von Willebrand factor antigen.This determines the level of von Willebrand factor in your blood by measuring a particular protein. 2. Von Willebrand factor activity.There are a variety of tests to measure how well the von Willebrand factor works in your clotting process. 3. Factor VIII clotting activity.This shows whether you have abnormally low levels and activity of factor VIII. 4. Von Willebrand factor multimers.This evaluates the structure of von Willebrand fac...
Even though von Willebrand disease has no cure, treatment can help prevent or stop bleeding episodes. Your treatment depends on: 1. The type and severity of your condition 2. How you've responded to previous therapy 3. Your other medications and conditions Your doctor might suggest one or more of the following treatments to increase your von Willebrand factor, strengthen blood clots or, in women, control heavy menstrual bleeding: 1. Desmopressin. This medication is available as an injection (DDAVP) or nasal spray (Minirin) It's a synthetic hormone that controls bleeding by stimulating your body to release more of the von Willebrand factor stored in the lining of your blood vessels. Many doctors consider DDAVP the first treatment for managing von Willebrand disease. Some women use the nasal spray at the beginning of their menstrual periods to control excessive bleeding. It can also be effective when used before a minor surgical procedure. 2. Replacement therapies. These include infus...
Explore Mayo Clinic studiestesting new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
These self-care tips can help you manage your condition: 1. Switch pain relievers.To help prevent bleeding episodes, talk with your doctor before taking blood-thinning medications — such as aspirin, ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve). Your doctor might instead recommend pain and fever relievers such as acetaminophen (Tylenol, others). 2. Tell your doctors and dentist.Let your doctors or dentist know that you have von Willebrand disease before you have surgery, start a new medication or give birth. Also mention whether anyone in your family has a history of excessive bleeding. 3. Consider wearing a medical ID bracelet.Make sure it notes that you have von Willebrand disease, which will be helpful to medical personnel if you're in an accident or taken to an emergency room. Also carry a medical alert card in your wallet. 4. Be active and safe.Exercise as part of attaining or maintaining a healthy weight. Avoid activities that could cause bruising, such as fo...
You'll likely see your family doctor if you think you have a bleeding problem. You then might be referred to a doctor who specializes in the diagnosis and treatment of bleeding disorders (hematologist). Here's some information to help you get ready for your appointment.
Pregnancy causes VWF levels to rise in most women, including many of those with VWD, which makes the disease harder to detect (Figure). As a result, the diagnostic evaluation must factor in a history of mucocutaneous bleeding and family history of VWD as well as abnormal results on VWF laboratory tests.
a laboratory-confirmed diagnosis. (C, IV) B. Persons without a definite diagnosis of VWD but with VWF:RCo levels of 30–50 IU/dL and a bleeding history may benefit from treatment or prophylaxis of bleeding in certain clinical situations. (B, III) 9 C. Persons with VWF:RCo >10 IU/dL and FVIII activity >20 IU/dL should undergo a trial of