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- During pregnancy, hormonal influences lead to an increase in vWF and clotting factors VII, VIII, and X while anticoagulant factors (such as protein S) decrease, shifting hemostasis to a procoagulant state to compensate for anticipated hemorrhage during parturition. 3 Although vWF and FVIII levels rise and peak during the third trimester, women with vWD remain at risk of early pregnancy bleeding, as well as postpartum hemorrhage (PPH), immediate and delayed. 4 This can be explained by the rapid...
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Does von Willebrand disease affect pregnancy and delivery?
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What is von Willebrand disease (vWD)?
How is von Willebrand disease diagnosed?
The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
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Given the wide heterogeneity of phenotypes and of the...
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Introduction. von Willebrand factor (VWF) is a multimeric...
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Dec 1, 2009 · Von Willebrand disease (VWD) encompasses a group of inherited bleeding disorders related to qualitative or quantitative defects of von Willebrand factor (VWF), which is essential in...
Apr 26, 2010 · Key words. hemorrhage. pregnancy. von Willebrand disease. A 26-year-old patient was seen for routine prenatal care. She had a history of delayed postpartum hemorrhage 4 years earlier after an uncomplicated vaginal delivery. During a recent visit to the dentist, she experienced increased bleeding after a tooth extraction.
Oct 26, 2021 · Von Willebrand disease diagnosis & treatment. CON-XXXXXXXX. Learn more about the symptoms, causes, diagnosis, treatment of this inherited bleeding disorder in which blood doesn't clot well.
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Many people with von Willebrand disease don't know it because the signs are mild or absent. The most common sign of the condition is abnormal bleeding.
There are three main types of the disease. The amount of bleeding varies from one person to another, depending on the type and severity of the disease.
If you have von Willebrand disease, you might have:
•Excessive bleeding from an injury or after surgery or dental work
•Frequent nosebleeds that don't stop within 10 minutes
•Heavy or long menstrual bleeding
Contact your doctor if you have bleeding that lasts a long time or is hard to stop.
Request an appointment
The usual cause of von Willebrand disease is an inherited abnormal gene that controls von Willebrand factor — a protein that plays a key role in blood clotting.
When you have low levels of this protein or it doesn't work as it should, small blood cells called platelets cannot stick together properly nor attach themselves normally to the blood vessel walls when an injury has occurred. This interferes with the clotting process and can sometimes cause uncontrolled bleeding.
Many people with von Willebrand disease also have low levels of factor VIII, another protein that helps in clotting.
Factor VIII is involved in another inherited clotting disorder called hemophilia. But unlike hemophilia, which mainly affects males, von Willebrand disease affects males and females and is usually milder.
The main risk factor for von Willebrand disease is having a family history of it. Parents pass the gene for the disease to their children. Rarely, the disease skips generations.
The disease is usually an "autosomal dominant inherited" disorder, which means you need a mutated gene from only one parent to get the disease. If you have the gene for von Willebrand disease, you have a 50% chance of transmitting this gene to your children.
Rarely, von Willebrand disease can cause uncontrollable bleeding, which can be life-threatening. Other complications of von Willebrand disease can include:
•Anemia. Heavy menstrual bleeding can cause iron deficiency anemia.
If you plan to have children and have a family history of von Willebrand disease, consider genetic counseling. If you carry the gene for von Willebrand disease, you can pass it on to your offspring, even if you don't have symptoms.
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By Mayo Clinic Staff
Oct 26, 2021
1.Von Willebrand disease. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/vwd/facts.html. Accessed Aug. 26, 2021.
2.AskMayoExpert. Von Willebrand disease. Mayo Clinic; 2021.
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Jun 16, 2023 · This topic reviews the clinical presentation, diagnosis, and differential diagnosis of VWD. Separate topic reviews discuss the treatment and pathophysiology of VWD, the diagnosis and treatment of acquired von Willebrand syndrome (AVWS), and a general approach to bleeding disorders.
Now known as von Willebrand disease In 1926, Erik von Willebrand first de- (VWD), this disorder is caused by either scribed a familial bleeding disorder in a quantitative or qualitative defect in von which symptoms were more severe in Willebrand factor (VWF). The preva-children and young women.
