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Specialty. Hematology. Von Willebrand disease ( VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion.
Von Willebrand disease is a bleeding disorder that slows the blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience easy bruising, long-lasting nosebleeds, and excessive bleeding or oozing following an injury, surgery, or dental work. Mild forms of von Willebrand disease may become ...
Von Willebrand disease is classified into 3 main types: Type 1: A quantitative deficiency of VWF, which is the most common form and is an autosomal dominant disorder. VWD concentration and activity are both reduced proportionally. Type 2: A qualitative impairment in synthesis and function of VWF that can result from various genetic ...
Von Willebrand disease (VWD) is the most common inherited bleeding disorder. Diagnosis can be challenging; some individuals with low von Willebrand factor (VWF) levels may not actually have VWD (or any bleeding disorder), whereas others who have never had a bleeding challenge or never been tested have a significant bleeding risk from VWD that ...
raise both von Willebrand factor levels and factor VIII levels in patients who respond and can be used during pregnancy for prophylaxis prior to invasive procedures such as amniocentesis. (2-4,10) Sánchez-Luceros et al noted no adverse events in 34 women with VWD who received a single dose of DDAVP immediately prior to epidural catheter placement.
Increased age, pregnancy, exercise, and stress may cause von Willebrand factor levels in the blood to rise, which can make bleeding symptoms less frequent. This disease is caused by genetic changes in the VWF gene and can have different inheritance patterns. Von Willebrand disease is a bleeding disorder that slows the blood clotting process.
Objective: von Willebrand disease (VWD) is a hereditary bleeding disorder. Type 3 VWD is the most severe and rare phenotype that presents many challenges for management of pregnant women. The aim of this study was to review the maternal characteristics and complications in pregnant women with Type 3 VWD. Study design: A systematic literature ...
